Rapid molecular diagnostic tests in patients with bacteremia: evaluation of their impact on decision making and clinical outcomes

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
K Z VardakasM E Falagas

Abstract

We performed a systematic review of the data regarding rapid diagnostic tests and their advantages or limitations on patients' clinical outcomes. The PubMed and Scopus databases were searched independently by two reviewers. Mortality was the primary outcome. Most studies compared rapid tests with blood cultures. Although not observed in all studies, only studies comparing rapid tests in conjunction with antimicrobial stewardship programs (ASPs) showed a mortality benefit. A reduction in hospital or intensive care unit (ICU) length of stay was also observed in almost all studies when the rapid tests, with or without ASPs, were used. Finally, treatment decisions were taken earlier in the rapid test groups. Despite a faster treatment decision, a clear mortality benefit was not seen when rapid tests were used. It is crucial to differentiate the influence of rapid tests from that of ASPs and clarify the actual effect of each factor separately.

References

May 25, 1994·JAMA : the Journal of the American Medical Association·D PittetR P Wenzel
Oct 6, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M H Kollef
Nov 30, 2004·The Lancet Infectious Diseases·Remco P H PetersChristina M J E Vandenbroucke-Grauls
Apr 26, 2006·The Journal of Antimicrobial Chemotherapy·Graeme N ForrestRichard A Venezia
May 1, 2007·The Pediatric Infectious Disease Journal·Enitan D CarrolC Anthony Hart
Jul 28, 2009·Critical Care Medicine·Lutz Eric LehmannFrank Stüber
Sep 29, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Omar M Al-RawajfahJeanne Beauchamp Hewitt
Apr 14, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V CattoirP Lesprit
Oct 1, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karri A BauerDebra A Goff
Dec 7, 2010·International Journal of Antimicrobial Agents·Michela PaolucciVittorio Sambri
Aug 10, 2011·Emergency Medicine Australasia : EMA·Shelley KirkbrightGrant W Waterer
Nov 15, 2011·Journal of Clinical Microbiology·Abigail M FryeMargret Oethinger
Dec 12, 2012·Archives of Pathology & Laboratory Medicine·Katherine K PerezJames M Musser
Jul 23, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Reetta HuttunenJanne Aittoniemi
Aug 1, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Angela M HuangJerod L Nagel
Jan 21, 2014·Journal of the American Geriatrics Society·Keith S KayeKenneth E Schmader
Jan 21, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jason M PogueKeith S Kaye

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Citations

Aug 30, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M OsthoffA Egli
May 26, 2017·PloS One·Antonio GalianaJuan Carlos Rodríguez
Feb 1, 2017·BMC Infectious Diseases·Matthias von RotzAdrian Egli
Nov 17, 2016·Journal of Clinical Microbiology·Erin McElvania TeKippe
Oct 23, 2019·The Journal of Applied Laboratory Medicine·Donna M Wolk, J Kristie Johnson
Mar 1, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jasmin Kaur JasujaIrene Burckhardt
Nov 28, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K Maelegheer, E Nulens
Dec 17, 2019·Therapeutic Advances in Infectious Disease·Patricia Jiménez-AguilarJesús Rodríguez-Baño
Jul 16, 2020·Critical Care : the Official Journal of the Critical Care Forum·Céline MonardUNKNOWN ADAPT study group
Jun 29, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S L Mitchell, K Alby
Jun 8, 2021·The Cochrane Database of Systematic Reviews·Vanesa Anton-VazquezTimothy Planche
Sep 7, 2021·Infection·Agustín Julián-JiménezUNKNOWN INFURG-SEMES investigators

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