Rapid multivortex mixing in an alternately formed contraction-expansion array microchannel

Biomedical Microdevices
Myung Gwon LeeJe-Kyun Park

Abstract

We report a contraction-expansion array (CEA) microchannel for rapidly and homogeneously mixing different types of fluids by multivortex induced in alternately formed rectangular structures of the channel. Rapid mixing can be achieved in a topologically simple and easily fabricated CEA microchannel, employing a synergetic combination of two kinds of vortices: (1) expansion-vortices being induced by flow separation due to an abrupt change of cross-sectional area of the channel in its expansion region, and (2) Dean-vortices being induced by centrifugal forces acting on a cornering fluid through the channel. We experimentally and numerically investigated expansion- and Dean-vortices, and demonstrated rapid mixing of an aqueous solution containing fluorescein or human red blood cells (RBCs) at different flow rates corresponding to Reynolds number (Re) ranging from 7.2 to 43.0. Over 90% mixing efficiency at a channel length of 14.4 and 19.5 mm was achieved at Re ≥ 28.6 (fluorescein solution and deionized water) and Re ≥ 21.5 (RBC suspension and phosphate buffered saline), respectively. The proposed CEA channel is expected to be useful for a wide range of applications where particles, cells and reagents must be rapidly and homogeneou...Continue Reading

References

Oct 17, 1998·Science·M A BurnsD T Burke
Feb 28, 2001·Chemistry : a European Journal·S M IvanovaS H Strauss
Jan 17, 2002·Analytical Chemistry·M H OddyJ C Mikkelsen
Jan 25, 2002·Analytical Chemistry·Timothy J JohnsonLaurie E Locascio
Jan 26, 2002·Science·Abraham D StroockGeorge M Whitesides
Apr 22, 2004·Lab on a Chip·Robin H LiuPiotr Grodzinski
Jul 27, 2004·Science·Julio M Ottino, Stephen Wiggins
Apr 28, 2005·Lab on a Chip·Peter B HowellFrances S Ligler
Dec 24, 2005·Lab on a Chip·Arjun P Sudarsan, Victor M Ugaz
Apr 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Arjun P Sudarsan, Victor M Ugaz
Aug 2, 2006·Analytical Chemistry·Palaniappan SethuMehmet Toner
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dino Di CarloMehmet Toner
Mar 4, 2009·Lab on a Chip·Wee Yang NgIsabel Rodríguez

❮ Previous
Next ❯

Citations

Jun 20, 2012·Biomedical Microdevices·Francesco PennellaUmberto Morbiducci
Jun 21, 2011·International Journal of Molecular Sciences·Chia-Yen LeeLung-Ming Fu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.