PMID: 2109320Apr 1, 1990Paper

Rapid neural regulation of muscle urokinase-like plasminogen activator as defined by nerve crush

Proceedings of the National Academy of Sciences of the United States of America
D HantaïB W Festoff

Abstract

Muscle plasminogen activators (PAs), such as urokinase-like PA and, to a lesser extent, tissue PA, increase dramatically after denervation induced by axotomy. The PA/plasmin system has also been implicated in degradation of specific components of the muscle fiber basement membrane after local activation of plasminogen. These results suggest that neural regulation of muscle extracellular matrix metabolism accompanies or precedes regeneration after injury and is mediated by activation of PAs. In the present study, we have used nerve crush to explore the neural regulation of muscle PA activities directly after subtotal axon interruption and during the process of reinnervation. Muscle contraction after nerve stimulation and estimation of choline acetyltransferase activity were used to monitor reinnervation. Within 24 hr of nerve crush, muscle urokinase (but not tissue PA) activity rose in soluble and membrane-bound muscle fractions, as shown by an amidolytic assay and a fibrin zymography. Membrane-bound activity was 5-fold higher than cytosol activity, but there was no shift between cellular compartments during the time course of denervation. Coincident with the return of choline acetyltransferase activity and muscle contractility,...Continue Reading

References

Feb 1, 1976·Experimental Neurology·J McLaughlin, H B Bosmann
Jul 1, 1978·The Journal of Experimental Medicine·A Granelli-Piperno, E Reich
Sep 1, 1979·Journal of Neurobiology·H L FernandezB W Festoff
Feb 11, 1988·Nature·R W Carrell
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D HantaïB W Festoff
Jan 1, 1987·Experimental Neurology·D Hantaï, B W Festoff
Jan 1, 1988·Annual Review of Cell Biology·O Saksela, D B Rifkin
Jan 18, 1966·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D Barker, M C Ip
Feb 27, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R Miledi, C R Slater
Mar 1, 1984·The Journal of Cell Biology·L I LarssonK Danø
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E G Levin
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·J R Sanes, A Y Chiu
May 1, 1983·Muscle & Nerve·J R SlackS Pockett
Sep 15, 1982·Thrombosis Research·M RånbyP Wallén
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·A MAURO

❮ Previous
Next ❯

Citations

Apr 1, 1994·Journal of Cellular Physiology·B W FestoffJ Chao
Sep 1, 1995·Journal of Cellular Physiology·F Vult von Steyern, J O Josefsson
Jul 23, 1999·Annals of the New York Academy of Sciences·M DemestreR A Hughes
Aug 5, 2000·Molecular and Cellular Neurosciences·H TangN Y Ip
Jun 6, 2006·Journal of Muscle Research and Cell Motility·Hualin SunXiaosong Gu
Sep 10, 2005·Neuropathology and Applied Neurobiology·M DemestreN A Gregson
Oct 29, 1993·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C J Marshall
Feb 26, 2019·Frontiers in Neurology·Barry W Festoff, Bruce A Citron

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.