Rapid nicotine clearance is associated with greater reward and heart rate increases from intravenous nicotine.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Mehmet SofuogluP I Jatlow

Abstract

The ratio of nicotine metabolites (trans-3'-hydroxycotinine (3HC) to cotinine) correlates with nicotine clearance. In previous studies, high nicotine metabolite ratio (NMR) predicted poor outcomes for smoking cessation treatment with nicotine patch. The underlying mechanisms that associate NMR with treatment outcomes have not been fully elucidated. A total of 100 smokers were divided into quartiles based on their baseline plasma NMR. Following overnight abstinence, smokers received saline followed by escalating intravenous doses of nicotine (0.5 and 1.0 mg/70 kg) given 30 min apart. The effects of nicotine on subjective, plasma cortisol, heart rate, and systolic and diastolic blood pressure measures were obtained. Smokers in the first NMR quartile (slower metabolizers) had lower Fagerstrom Test for Nicotine Dependence (FTND) scores, suggesting lower levels of dependence. In contrast, smokers in the fourth NMR quartile (faster metabolizers) reported greater craving for cigarettes following overnight abstinence from smoking and reported greater ratings of nicotine-induced good drug effects, drug liking, and wanting more drug. Higher NMR was also associated with greater heart rate increases in response to nicotine. These results s...Continue Reading

References

Dec 1, 1991·British Journal of Addiction·M W Fischman, R W Foltin
Mar 1, 1986·Archives of General Psychiatry·J R Hughes, D Hatsukami
Apr 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·D E Comings
Jan 1, 1997·Journal of Substance Abuse·J R Hughes, D K Hatsukami
Jun 11, 1998·Psychoneuroendocrinology·W B Pickworth, R V Fant
Aug 12, 1998·The American Journal of Psychiatry·E A SteinA S Bloom
Aug 17, 2000·Clinical Pharmacology and Therapeutics·E M SellersR F Tyndale
Feb 13, 2001·British Journal of Clinical Pharmacology·N L Benowitz, P Jacob
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Delia DempseyNeal L Benowitz
May 25, 2002·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·UNKNOWN SRNT Subcommittee on Biochemical Verification
Aug 15, 2002·Pharmacology, Biochemistry, and Behavior·Mustafa al'AbsiLorentz E Wittmers
Nov 6, 2002·Psychopharmacology·Jesse DalleryMaxine L Stitzer
May 22, 2003·Drug and Alcohol Dependence·Roland R GriffithsNancy A Ator
Oct 28, 2003·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Neal L BenowitzPeyton Jacob
Nov 25, 2003·Psychopharmacology·Ismene L PetrakisUNKNOWN VA Naltrexone Study Collaboration Group
Dec 12, 2003·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Mehmet SofuogluDorothy K Hatsukami
Jul 2, 2004·Clinical Pharmacology and Therapeutics·Delia DempseyNeal L Benowitz
Mar 1, 2005·Pharmacological Reviews·Janne HukkanenNeal L Benowitz
May 5, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jack H MendelsonNancy K Mello
Jun 29, 2005·Psychopharmacology·Mehmet SofuogluThomas Kosten
Jan 25, 2006·Psychopharmacology·Mehmet SofuogluThomas Kosten
May 9, 2006·Clinical Pharmacology and Therapeutics·Neal L BenowitzPeyton Jacob
Jun 13, 2006·Clinical Pharmacology and Therapeutics·Caryn LermanNeal Benowitz
Oct 4, 2006·Clinical Pharmacology and Therapeutics·Elaine JohnstoneRobert Walton
Nov 23, 2006·Clinical Pharmacology and Therapeutics·Neal L BenowitzRachel F Tyndale
Jan 9, 2007·Journal of Pharmacokinetics and Pharmacodynamics·Micha LeviLewis B Sheiner
Feb 27, 2007·American Journal of Epidemiology·Denise B KandelNeal L Benowitz
May 31, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mehmet SofuogluMarc Mooney
Apr 5, 2008·Clinical Pharmacology and Therapeutics·F PattersonC Lerman
Jun 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Marc E MooneyDorothy K Hatsukami
Sep 3, 2008·Pediatrics·Mark L RubinsteinAnna-Barbara Moscicki
Nov 13, 2008·Pharmacology, Biochemistry, and Behavior·Robert A SchnollCaryn Lerman
Dec 2, 2008·Pharmacology, Biochemistry, and Behavior·Mehmet SofuogluStephanie S O'Malley
Feb 3, 2009·Handbook of Experimental Pharmacology·Neal L BenowitzPeyton Jacob
Feb 3, 2009·Handbook of Experimental Pharmacology·Jill C Mwenifumbo, Rachel F Tyndale
Mar 21, 2009·Pharmacogenetics and Genomics·Gary E SwanNeal L Benowitz
May 6, 2009·Journal of Abnormal Psychology·Saul Shiffman, Thomas R Kirchner
Oct 30, 2010·The International Journal of Neuropsychopharmacology·Irina EsterlisKelly P Cosgrove
Jan 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Andrew A StrasserCaryn E Lerman
May 18, 2011·Journal of Abnormal Psychology·David R StrongRaymond Niaura
Jul 13, 2011·Journal of the National Cancer Institute·Catherine A WassenaarRachel F Tyndale

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Citations

Jan 22, 2014·Pharmacogenomics·Aryeh I HermanMehmet Sofuoglu
Dec 19, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elise E DeVitoMehmet Sofuoglu
Dec 29, 2012·Psychopharmacology·Meghan E MoreanStephanie S O'Malley
Dec 6, 2014·Behavioural Neurology·Philip Adeyemi AdeniyiOlalekan Michael Ogundele
Jan 19, 2016·Drug and Alcohol Dependence·Gerald W ValentineMehmet Sofuoglu
Jan 26, 2016·Biological Psychiatry·Mary FalconeCaryn Lerman
Dec 9, 2015·Drug and Alcohol Dependence·Meghan J ChenowethRachel F Tyndale
May 8, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kevin P JensenMehmet Sofuoglu
Jun 13, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Meghan J ChenowethRachel F Tyndale
Apr 22, 2015·CNS Drugs·Michael MamounArthur L Brody
Mar 13, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Andrea H WeinbergerSherry A McKee
Dec 24, 2014·The Pharmacogenomics Journal·K P JensenM Sofuoglu
Apr 25, 2016·Drug and Alcohol Dependence·Noah R GubnerMaciej L Goniewicz
Oct 8, 2016·Trends in Pharmacological Sciences·Meghan J Chenoweth, Rachel F Tyndale
Nov 14, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Hera E SchlagintweitSean P Barrett
Jun 6, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Paula L Vieira-BrockDiana G Wilkins
Jan 25, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul FaulknerEdythe D London
Apr 8, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Brian V FixJames F Thrasher
May 2, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Stephen R BaldassarriIrina Esterlis
Mar 8, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kenneth A PerkinsMargaret C Boldry
Dec 2, 2017·Journal of Personalized Medicine·Julie-Anne Tanner, Rachel F Tyndale
Oct 31, 2017·Journal of Dual Diagnosis·Gerald W ValentineMehmet Sofuoglu
May 24, 2018·Journal of Psychopharmacology·Gerald W ValentineMehmet Sofuoglu
Nov 23, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Alicia M AllenSherry A McKee
Jan 19, 2018·The International Journal of Neuropsychopharmacology·Patricia Di CianoBernard Le Foll
Aug 11, 2018·Expert Review of Respiratory Medicine·Nikki Bozinoff, Bernard Le Foll
Nov 6, 2015·Circulation. Cardiovascular Genetics·Allan LinnebergLise Lotte N Husemoen
Nov 7, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Robert A SchnollRebecca L Ashare
Sep 23, 2018·Clinical Pharmacology and Therapeutics·Evangelia LiakoniNeal L Benowitz
Apr 17, 2013·Clinical Pharmacology and Therapeutics·K J BoughS Amur
Apr 18, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Elise E DeVitoMehmet Sofuoglu
Nov 15, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Evangelia LiakoniNeal L Benowitz
Apr 3, 2020·Current Pharmaceutical Design·Antonio Cepeda-Benito
Jan 1, 2014·Journal of Neurodegenerative Diseases·Duyilemi Chris AjonijebuOlalekan Michael Ogundele
Apr 17, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ilse P I Van OvermeireKoen A J De Cremer

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