Rapid Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanorods and Nanotriangles for Colorimetric Single-Nucleotide Discrimination

Chemistry : a European Journal
Guoqing WangMizuo Maeda

Abstract

Gold nanoparticles modified with DNA duplexes are rapidly and spontaneously aggregated at high ionic strength. In contrast, this aggregation is greatly suppressed when the DNA duplex has a single-base mismatch or a single-nucleotide overhang located at the outermost surface of the particle. These colloidal features emerge irrespective of the size and composition of the particle core; however, the effects of the shape remain unexplored. Using gold nanorods and nanotriangles (nanoplatelets), we show herein that both remarkable rapidity in colloidal aggregation and extreme susceptibility to DNA structural perturbations are preserved, regardless of the shape and aspect ratio of the core. It is also demonstrated that the DNA-modified gold nanorods and nanotriangles are applicable to naked-eye detection of a single-base difference in a gene model. The current study corroborates the generality of the unique colloidal properties of DNA-functionalized nanoparticles, and thus enhances the feasibility of their practical use.

References

Jul 3, 2003·Journal of the American Chemical Society·Kae SatoMizuo Maeda
Jul 2, 2004·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Kae SatoMizuo Maeda
Mar 4, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Takeshi Mori, Mizuo Maeda
Apr 14, 2005·Chemical Reviews·Nathaniel L Rosi, Chad A Mirkin
Nov 1, 2005·Nucleic Acids Research·Jishan LiRu-Qin Yu
Nov 16, 2007·Chemical Communications : Chem Comm·Daisuke MiyamotoMizuo Maeda
Jan 18, 2008·Analytical Chemistry·Colin D MedleyWeihong Tan
Sep 30, 2008·Chembiochem : a European Journal of Chemical Biology·Weian ZhaoYingfu Li
Jul 31, 2009·Chemical Communications : Chem Comm·Atsushi Ogawa, Mizuo Maeda
Feb 5, 2010·Biosensors & Bioelectronics·Guoqing WangJaebum Choo
Oct 5, 2010·Nature Materials·Matthew R JonesChad A Mirkin
Dec 7, 2011·Journal of Colloid and Interface Science·Masahiro FujitaMizuo Maeda
Mar 6, 2012·Journal of Colloid and Interface Science·Wei-Yang OoiMizuo Maeda
Sep 28, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Pengju PanMizuo Maeda
Jul 19, 2013·Chemical Communications : Chem Comm·Tong BuMizuo Maeda
Jul 23, 2013·Chemistry : a European Journal·Naoki KanayamaMizuo Maeda

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Citations

May 14, 2016·Nanoscale·Paola ValentiniPier Paolo Pompa
Feb 9, 2016·The Analyst·Zhiqin YuanChao Lu
Jun 21, 2018·The Analyst·Amir GhasemiMichael R Hamblin
Nov 12, 2020·Biosensors·Zhiyu HeXingguo Liang
Dec 8, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hiroya NakauchiNaoki Kanayama
Oct 20, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Zhiyu HeMizuo Maeda
Dec 14, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Naoki KanayamaMizuo Maeda
Aug 8, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Zhonglan TangMizuo Maeda
Aug 14, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Lan ZhangXingguo Liang

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