Rapid nongenomic effects of aldosterone on the renal vasculature in humans

Hypertension
Bernhard M W SchmidtRoland E Schmieder

Abstract

There is increasing evidence for the importance of rapid nongenomic effects of aldosterone on the human vasculature. In vitro animal experiments in renal arterioles also suggest the presence of such effects on the renal vasculature. We conducted a clinical study to explore these effects in vivo in humans. Thirteen healthy male volunteers were examined. Aldosterone (500 microg) or placebo was injected intravenously with or without coinfusion of N(G) monomethyl-L-arginine (L-NMMA) in a randomized, double-blinded 4-fold crossover design. Renal plasma flow and glomerular filtration rate were measured by constant infusion clearance technique using inulin and para-aminohippuric acid. Injection of aldosterone without concomitant infusion of L-NMMA changed the renal plasma flow and glomerular filtration rate not statistically significant compared with placebo. Coinfusion of L-NMMA unmasked the effect of aldosterone: aldosterone with L-NMMA decreased the glomerular filtration rate slightly (-1.4+/-6.2 mL/min), whereas infusion of L-NMMA alone increased the glomerular filtration rate (8.3+/-9.8 mL/min; P=0.004). L-NMMA alone decreased renal plasma flow by 58.2+/-97.5 mL/min, and aldosterone with L-NMMA decreased renal plasma flow by 190....Continue Reading

References

Dec 1, 1994·Statistical Methods in Medical Research·J N Matthews
Jun 1, 1997·Journal of the American Society of Nephrology : JASN·R E SchmiederF C Luft
Feb 9, 2000·Frontiers in Neuroendocrinology·B M SchmidtM Wehling
Feb 27, 2001·Current Opinion in Nephrology and Hypertension·J W Funder
Feb 5, 2002·American Journal of Hypertension·Douglas E Vaughan
Jan 9, 2003·American Journal of Hypertension·Bernhard M W Schmidt, Roland E Schmieder
Jul 16, 2003·Hypertension·Bernhard M W SchmidtRoland E Schmieder
Aug 26, 2003·Journal of the American Society of Nephrology : JASN·Shuji ArimaSadayoshi Ito
Nov 15, 2003·Circulation Research·T R UhrenholtO Skøtt
Dec 4, 2003·American Journal of Hypertension·Christian DellesRoland E Schmieder
Jun 18, 2004·Kidney International·Norman K Hollenberg
Jul 31, 2004·Acta Physiologica Scandinavica·K Skov, M J Mulvany
Jul 31, 2004·Acta Physiologica Scandinavica·T R UhrenholtO Skøtt
Jan 27, 2005·The American Journal of Cardiology·Prasad GunaruwanMichael Frenneaux

❮ Previous
Next ❯

Citations

Nov 20, 2008·Pflügers Archiv : European journal of physiology·L WildlingH Oberleithner
Nov 20, 2008·Pflügers Archiv : European journal of physiology·Michael Gekle, Claudia Grossmann
Sep 3, 2010·Pflügers Archiv : European journal of physiology·Johannes FelsHans Oberleithner
May 10, 2007·International Urology and Nephrology·Robert D Lindeman
Jun 17, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Julia Reuter, Jens Jordan
Jun 16, 2011·European Heart Journal·Mazen AlbaghdadiBertram Pitt
Jun 30, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Katrine J SchjoedtHans-Henrik Parving
Oct 28, 2009·Journal of Cardiovascular Pharmacology·Jane A Leopold
Sep 28, 2013·European Journal of Internal Medicine·João Pedro FerreiraHenrique Carvalho
Jul 26, 2011·International Journal of Hypertension·P StiefelJ Villar
Jul 16, 2008·Journal of Hypertension·Arttu ErärantaIlkka H Pörsti
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Tae-Yon Chun, J Howard Pratt
Jul 1, 2006·Expert Opinion on Drug Discovery·Eric R ProssnitzTudor I Oprea
Aug 2, 2011·Molecular and Cellular Endocrinology·Ruth DooleyWarren Thomas
Jun 25, 2009·Molecular and Cellular Endocrinology·C Grossmann, M Gekle
Nov 3, 2007·Frontiers in Neuroendocrinology·Ralf M Lösel, Martin Wehling
Sep 16, 2014·Journal of Renal Care·Eric Wombwell, Andrew Naglich
Oct 19, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Shuji Arima
Jan 12, 2007·The Journal of Clinical Hypertension·Daniel A Duprez
Feb 8, 2008·The Journal of Clinical Hypertension·Sameer StasJames R Sowers
Apr 16, 2008·Clinical Endocrinology·Andrea VerhovezPaolo Mulatero
Mar 23, 2010·Biochimica Et Biophysica Acta·Johannes FelsKristina Kusche-Vihrog
Dec 28, 2010·Journal of Pharmacological Sciences·Kazi RafiqAkira Nishiyama
Jan 28, 2017·The Journal of Steroid Biochemistry and Molecular Biology·Martin Wehling
Jan 28, 2009·Therapeutic Advances in Cardiovascular Disease·Monica CortinovisGiuseppe Remuzzi
Nov 23, 2012·Journal of Vascular Research·Marie Briet, Ernesto L Schiffrin
Mar 30, 2017·The Journal of Endocrinology·Stefanie RuhsClaudia Grossmann
May 16, 2007·Hypertension·Fabian NietlispachHans Peter Brunner-La Rocca
Mar 8, 2006·Hypertension·Tae-Yon Chun, J Howard Pratt
Feb 21, 2007·Hypertension·David W Good
Jul 9, 2008·Hypertension·Tae-Yon ChunJ Howard Pratt
Aug 19, 2020·The Journal of Clinical Hypertension·Decio ArmaniniLuciana Bordin
Dec 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrés A HerradaAlexis M Kalergis
Jan 29, 2019·Frontiers in Physiology·Zachary J SchladerBlair D Johnson
Mar 5, 2020·Journal of Veterinary Pharmacology and Therapeutics·Sarah SpencerJonathan Elliott
Aug 9, 2007·Clinical Science·Annis M Marney, Nancy J Brown
Sep 19, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Vasiliki BistolaJohn Parissis
Jun 15, 2021·Frontiers in Molecular Biosciences·Yekatarina GadashevaClaudia Grossmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.