Rapid, nongenomic estrogen actions protect pancreatic islet survival.

Islets
Suhuan Liu, Franck Mauvais-Jarvis

Abstract

The gonadal steroid, 17beta-estradiol (E(2)), acts as a protective hormone preventing beta-cell apoptosis in vivo in mice of both sexes and in cultured mouse and human islets. E(2) signals via the classical estrogen receptor (ER)alpha and ERbeta, an extranuclear form of ERalpha and the G protein-coupled estrogen receptor (GPER). In a recent study, we determined the contribution of these receptors to beta-cell survival, using a combination of genetic and pharmacological tools in mice and cultured mouse and human islets. We showed that E(2) favors islet survival by preventing apoptosis via ERalpha and ERbeta through ERE-independent, extra-nuclear mechanisms and with a predominant ERalpha effect. We also revealed that E(2) prevents apoptosis via GPER-dependent mechanisms. Here, we show that E(2) prevents apoptosis independently of gene transcription or de novo protein synthesis suggesting that E(2) cytoprotection happens independently of nuclear events. Furthermore, we report that E(2) islet cytoprotection can be mimicked by the nonfeminizing E(2) stereoisomer, 17alpha-estradiol, suggesting that it is partially non-estrogen receptor mediated. These studies identify novel estrogen pathways and targets to protect islet survival.

Citations

Aug 17, 2011·Nature Reviews. Endocrinology·Eric R Prossnitz, Matthias Barton
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Winifred P S WongFranck Mauvais-Jarvis
Dec 8, 2009·Endocrinology·Suhuan Liu, Franck Mauvais-Jarvis
Mar 6, 2013·Endocrine Reviews·Franck Mauvais-JarvisAndrea L Hevener
Jan 23, 2016·Diabetologia·Mehboob A HussainWoo-Jin Song
Nov 27, 2010·Trends in Endocrinology and Metabolism : TEM·Franck Mauvais-Jarvis
Jun 3, 2015·Molecular and Cellular Endocrinology·Andrea L HevenerFranck Mauvais-Jarvis
Sep 22, 2011·Cancer·Lorraine L LipscombePaula A Rochon
Apr 18, 2015·Journal of Diabetes Research·Anisha A GupteDale J Hamilton
Dec 3, 2014·Diabetes & Metabolism·N Chevalier, P Fénichel
May 12, 2016·Cell Metabolism·Matthew Wortham, Maike Sander
May 11, 2019·Endocrine Reviews·Sandra Handgraaf, Jacques Philippe
Sep 25, 2018·Current Opinion in Organ Transplantation·Elisabeth Kemter, Eckhard Wolf
Sep 7, 2019·PloS One·Surl-Hee AhnJake A Kushner
Apr 17, 2020·Frontiers in Endocrinology·Jing Luo, Dongmin Liu
Feb 15, 2012·Nature Reviews. Endocrinology·Joseph P Tiano, Franck Mauvais-Jarvis
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Rachel BleachMarie McIlroy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis