PMID: 696327Aug 1, 1978Paper

Rapid oncogenesis in vivo by chicken retrovirus OK10

Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology
L Hortling

Abstract

The OK10 virus complex is known to contain two detectable viruses: a) focue-forming virus OK10V that transforms chick embryo cells, and b) an associated virus OK10AV present in excess that converts the morphology of cultured chick embryo cells. The pathogenesis of OK10 virus infection was studied, using 2--4 day old Brown Leghorn chickens. A group of chickens was sacrificed at weekly intervals, serum samples were taken and tissues were examined for virus. Autopsies of the chicken were performed and gross and microscopic changes were registered. After intraperitoneal injection of 10(4) focus-forming units of OK10 virus, infectious OK10AV was detected after one week in Bursa Fabricius, thymus and liver, and OK10V after two weeks in Bursa Fabricius but in no other organ. Neutralizing serum antibodies developed within three weeks. The first malignant changes, in the mesentery, were detected after three weeks. The infection was lethal in all experiments within 6--8 weeks. In the mesentery, the tumors consisted of large tumour cells with clear cytoplasm, a large nucleus and prominent nucleoli. The origin of these cells could not be established. The cells were surrounded by lymphoid cells. From the tumours, vontinuous cell lines were ...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.