Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD): Response to ventilatory challenges

Pediatric Pulmonology
Michael S CarrollDebra E Weese-Mayer

Abstract

Hypoventilation is a defining feature of Rapid-onset Obesity with Hypothalamic dysfunction, Hypoventilation and Autonomic Dysregulation (ROHHAD), a rare respiratory and autonomic disorder. This chronic hypoventilation has been explained as the result of dysfunctional chemosensory control circuits, possibly affecting peripheral afferent input, central integration, or efferent motor control. However, chemosensory function has never been quantified in a cohort of ROHHAD patients. Therefore, the purpose of this study was to assess the response to awake ventilatory challenge testing in children and adolescents with ROHHAD. The ventilatory, cardiovascular and cerebrovascular responses in 25 distinct comprehensive physiological recordings from seven unique ROHHAD patients to three different gas mixtures were analyzed at breath-to-breath and beat-to-beat resolution as absolute measures, as change from baseline, or with derived metrics. Physiologic measures were recorded during a 3-min baseline period of room air, a 3-min gas exposure (of 100% O2; 95% O2, 5% CO2; or 14% O2, 7% CO2 balanced with N2), and a 3-min recovery period. An additional hypoxic challenge was conducted which consisted of either five or seven tidal breaths of 100% N2...Continue Reading

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Aug 3, 2011·Pediatrics·Pallavi P PatwariDebra E Weese-Mayer
Jan 2, 2014·Journal of Applied Physiology·Michael S CarrollDebra E Weese-Mayer

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Citations

May 6, 2016·Pediatric Pulmonology·Jean-Paul Praud
Jun 25, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·S Ibáñez-MicóR Domingo Jiménez
Jul 31, 2016·Orphanet Journal of Rare Diseases·Diana ReppucciIndra Narang
Sep 30, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Maria FilippidouChristina Kanaka-Gantenbein
Jul 22, 2018·Orphanet Journal of Rare Diseases·Sarah F BarclayDebra E Weese-Mayer
Nov 25, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Hina EmanuelCindy Jon
Dec 18, 2020·Frontiers in Pediatrics·Gizem ÖzcanNazan Çobanoğlu
Sep 18, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Radhika GhoshAjay S Kasi

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