Rapid onset of control with budesonide Turbuhaler in patients with mild-to-moderate asthma

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
J P KempJ Grossman

Abstract

Budesonide (Pulmicort) is an inhaled corticosteroid with high topical potency but low systemic activity. Turbuhaler is a novel breath-actuated, multi-dose, dry-powder inhaler. This study was conducted to determine the efficacy and safety of two different dose regimens of budesonide Turbuhaler, compared with placebo, in adult patients with mild-to-moderate asthma not well-controlled with bronchodilator therapy. This double-blind, randomized, placebo-controlled, parallel-group, multicenter study compared the efficacy and safety of 200 microg and 400 microg of budesonide, administered twice daily via Turbuhaler, with placebo, in 273 adult patients (aged 19 to 70 years) with mild-to-moderate asthma (FEV1 67% of predicted normal), not well-controlled with bronchodilator therapy. Efficacy was assessed by pulmonary function tests and patient assessments of asthma symptom control. Safety was assessed in terms of adverse events, laboratory evaluations, and physical examinations. Two hundred and 400 microg of budesonide bid were significantly more effective than placebo at improving morning PEF (mean differences from placebo of 43.63 L/min and 40.10 L/min, respectively; P < .001) and FEV1 (mean differences from placebo of 0.44 L, and 0.5...Continue Reading

References

Apr 1, 1977·The Journal of Allergy and Clinical Immunology·J H ToogoodL Chuang
Jul 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·J H van den BergJ H Thijssen
Dec 1, 1992·Thorax·B J Smith
Jun 1, 1992·Thorax·D M Geddes
Oct 1, 1991·Allergy·T EngelS A Johansson
Oct 1, 1990·Thorax·S LorentzsonG Persson
Jun 1, 1991·The American Review of Respiratory Disease·A S VathenenA E Tattersfield
Aug 1, 1990·The American Review of Respiratory Disease·R DjukanovićS T Holgate
Nov 30, 1989·The New England Journal of Medicine·P J Barnes
Jan 1, 1995·The Journal of Allergy and Clinical Immunology·S Pedersen, O R Hansen
Oct 1, 1994·The European Respiratory Journal·L ThorssonT B Conradson
Mar 30, 1995·The New England Journal of Medicine·P J Barnes
Apr 1, 1994·Respiratory Medicine·A H JonesP D Richardson
Sep 15, 1994·The New England Journal of Medicine·T HaahtelaA Sovijärvi
Sep 1, 1996·The Journal of Allergy and Clinical Immunology·Jean BousquetF Neukirch

Citations

May 5, 2004·Pulmonary Pharmacology & Therapeutics·Hanneke J van der WoudeRené Aalbers
Jan 10, 2002·Journal of Clinical Epidemiology·Karen M KuntzScott T Weiss
Mar 24, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·G S RachelefskyRab Faruqi
Apr 3, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·T B CasaleBengt Liljas
Jun 29, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Charles H BanovW Lumry
Oct 27, 2001·BMJ : British Medical Journal·C Cates
Jul 23, 2004·International Journal of Adolescent Medicine and Health·Petr Pohunek, Asher Tal
Jul 5, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·L J Smith
Apr 19, 2008·Current Medical Research and Opinion·Edward M KerwinSteven G Simonson
Aug 8, 2006·Respiratory Medicine·Björn StällbergB A Hermansson
Mar 16, 2017·Equine Veterinary Journal·L CalzettaM G Matera
Nov 28, 2001·São Paulo Medical Journal = Revista Paulista De Medicina·A L FernandesJ R Jardim
Mar 30, 2004·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Charles H Banov
Nov 1, 2001·The Cochrane Database of Systematic Reviews·N AdamsP W Jones
Jun 17, 2003·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·David G TinkelmanSheldon L Spector
Mar 9, 2002·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·W J MetzgerMark Sugar

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