Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications

Journal of Controlled Release : Official Journal of the Controlled Release Society
Janine JansenDirk W Grijpma

Abstract

Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NVP and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release.

Citations

Jul 18, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohamed A Shaker, Husam M Younes
Nov 5, 2011·Macromolecular Bioscience·Jukka SeppäläMinna Malin
Dec 1, 2018·Journal of Biomaterials Science. Polymer Edition·Bas van Bochove, Dirk W Grijpma
May 30, 2019·Critical Reviews in Biotechnology·Joseph SebastianSatinder Kaur Brar
Aug 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hao WangXian-He Bu
Dec 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ju Young ParkDong-Woo Cho

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