Rapid, postmortem 9.4 T MRI of spinal cord injury: correlation with histology and survival times

Journal of Neuroscience Methods
Felix ScholtesJean Schoenen

Abstract

High field magnetic resonance imaging (MRI) has been increasingly used to assess experimental spinal cord injury (SCI). In the present investigation, after partial spinal cord injury and excision of the whole spine, pathological changes of the spinal cord were studied in spinal cord-spine blocks, from the acute to the chronic state (24 h to 5 months). Using proton density (PD) weighted imaging parameters at a magnetic field strength of 9.4 tesla (T), acquisition times ranging from <1 to 10 h per specimen were used. High in-plane pixel resolution (68 and 38 microm, respectively) was obtained, as well as high signal-to-noise ratio (SNR), which is important for optimal contrast settings. The quality of the resulting MR images was demonstrated by comparison with histology. The cord and the lesion were shown in their anatomical surroundings, detecting cord swelling in the acute phase (24 h to 1 week) and cord atrophy at the chronic stage. Haemorrhage was detected as hypo-intense signal. Oedema, necrosis and scarring were hyper-intense but could not be distinguished. Histology confirmed that the anatomical delimitation of the lesion extent by MRI was precise, both with high and moderate resolution. The present investigation thus demo...Continue Reading

References

Nov 1, 1977·The Histochemical Journal·C L Scholtz
Apr 22, 1988·Neuroscience Letters·J W LittleR C Sohlberg
Oct 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J C FalconerS J Liu
Feb 1, 1997·Investigative Radiology·V M RungeD A Blades
Mar 1, 1997·Journal of Neurosurgery·C H Tator, I Koyanagi
Oct 24, 1998·Experimental Neurology·M FraidakisC Spenger
Oct 29, 1999·Clinical Radiology·P Corr, S Govender
Apr 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M BilgenP A Narayana
Apr 3, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M BilgenP A Narayana
Aug 6, 2003·Current Opinion in Immunology·Robia G Pautler, Scott E Fraser
Nov 25, 2003·Current Opinion in Neurobiology·Dae-Shik Kim, Michael Garwood
Apr 2, 2004·Neurobiology of Disease·Jean-Marie BonnyJean-Pierre Renou
Jun 12, 2004·Experimental Neurology·Matthew J FraidakisLars Olson
Aug 25, 2004·Behavioural Brain Research·Aubrey A Webb, Gillian D Muir
Oct 23, 2004·Journal of Neuroscience Research·Ponnada A NarayanaRussell Vang
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Edward D Hall, Joe E Springer
Feb 22, 2005·Current Opinion in Biotechnology·J Michael TyszkaRussell E Jacobs
Nov 4, 2005·Journal of Neurosurgery. Spine·Christopher B ShieldsNorman W Mayer
Feb 4, 2006·Journal of Neuroscience Research·Aparna A DeoPonnada A Narayana
Feb 28, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiang DengPonnada A Narayana

❮ Previous
Next ❯

Citations

May 10, 2012·Frontiers in Neuroendocrinology·Lauren V Riters
May 7, 2011·Magnetic Resonance Imaging·Ann S ChoeAdam W Anderson
Apr 5, 2012·The Journal of Comparative Neurology·Kathryn S McDonald, John R Kirn
Jul 22, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Andrew C LaingThomas Oxland
Oct 30, 2021·Journal of Neurotrauma·Basavaraju G SanganahalliSridhar S Kannurpatti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.