PMID: 9169573Jun 1, 1997Paper

Rapid preparation method for technetium-99m bicisate

European Journal of Nuclear Medicine
J C HungDouglas W Mahoney

Abstract

The method currently recommended for the preparation of technetium-99m bicisate (99mTc-bicisate) requires a lengthy 30-min incubation at room temperature. The purpose of this study was to evaluate an alternative method to shorten the preparation time. 99mTc-bicisate was prepared with 3.7 GBq (100 mCi) 99mTc according to the manufacturer's instructions, except for the final incubation step, which was replaced with the microwave heating procedure. A standard thin-layer chromatography (TLC) method (i.e., Baker-Flex silica gel IB-F TLC plate with ethyl acetate as mobile phase) was used for the determination of the radiochemical purity (RCP) of 99mTc-bicisate. Our evaluation with different microwave heating processes (300 W with different heating times) demonstrated that as the microwave heating temperature was increased (i.e., 44 masculine-71 masculine C), an increased percentage of samples reached 95% within 5 min post preparation (n=58). The highest RCP value (i.e., 97.4%+/-0.5%, n=10) could be obtained immediately after an 8-s microwave heating time at 300 W (microwave temperature at 69 masculine C), and an average RCP value of 96.4%+/-1.3% (n=90) was maintained throughout the 24-h evaluation period. However, the trend seemed to...Continue Reading

References

Jan 1, 1990·Seminars in Nuclear Medicine·D EshimaA Taylor

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Citations

Mar 20, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·T J O'BrienC R Jack
Jun 29, 2002·Nuclear Medicine and Biology·K VerbekeA Verbruggen

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