Rapid Progression of Coronary Atherosclerosis: A Review

Thrombosis
Priyank ShahFayez Shamoon

Abstract

Atherosclerosis is chronic disease, the prevalence of which has increased steadily as the population ages. Vascular injury is believed to be critical initiating event in pathogenesis of spontaneous atherosclerosis. Syndrome of accelerated atherosclerosis has been classically described in patients undergoing heart transplantation, coronary artery bypass graft, and percutaneous transluminal coronary angioplasty. In contrast to spontaneous atherosclerosis, denuding endothelial injury followed by thrombus formation and initial predominant smooth muscle cell proliferation is believed to be playing a significant role in accelerated atherosclerosis. There is no universal definition of rapid progression of atherosclerosis. However most studies describing the phenomenon have used the following definition: (i) > or = 10% diameter reduction of at least one preexisting stenosis > or = 50%, (ii) > or = 30% diameter reduction of a preexisting stenosis <50%, and (iii) progression of a lesion to total occlusion within few months. Recent studies have described the role of coronary vasospasm, human immunodeficiency virus, various inflammatory markers, and some genetic mutations as predictors of rapid progression of atherosclerosis. As research i...Continue Reading

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Citations

Jan 15, 2019·Current Pharmaceutical Design·Virna M Martín GiménezWalter Manucha
Apr 25, 2020·The Journal of International Medical Research·Chao FengShudong Xia
Aug 23, 2019·International Journal of Molecular Medicine·Zhiqiang HeNianlong Yan
Aug 2, 2017·Canadian Journal of Physiology and Pharmacology·Lan YuHongxin Wang
Dec 1, 2019·Journal of Clinical Medicine·Natalie C WardGerald F Watts

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Methods Mentioned

BETA
coronary
percutaneous transluminal coronary angioplasty
ESR

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