Rapid protection of the gastroduodenal mucosa against aspirin-induced damage by rabeprazole

Alimentary Pharmacology & Therapeutics
S IraniR S Fisher

Abstract

The ability of a proton pump inhibitor to reduce or prevent NSAID-induced gastroduodenal damage during the first 24 h has not been tested. To determine, whether oral rabeprazole, administered 5 h before the initiation of therapeutic dosing of aspirin protects the gastroduodenal mucosa. Normal subjects were randomized into two groups - one received rabeprazole, 20 mg at 07:00 hours and the other placebo, before initiation of aspirin 650 mg at 12:00 hours, and then q4 h for 3 days. Upper endoscopic examinations were performed on all subjects at baseline, 24 and 72 h after initiation of aspirin. Gastroduodenal mucosal damage was scored. Thirty subjects were compliant with study medications and underwent three endoscopic examinations. Salicylate concentrations were similar for the placebo and the rabeprazole groups at all times. On rabeprazole, the Lanza scores were significantly lower compared with placebo at 24 h (1.3 +/- 0.26 vs. 2.1 +/- 0.26, P < 0.05) and at 72 h (1.3 +/- 0.29 vs. 2.3 +/- 0.28, P < 0.05). Gastric antral erosion counts were less with rabeprazole than placebo at 24 (4.1 +/- 1.3 vs. 7.6 +/- 2.0, P > 0.05) and 72 h (5.3 +/- 1.8 vs. 8.0 +/- 1.5; P > 0.05). Rabeprazole, initiated 5 h before the start of therapeutic ...Continue Reading

References

Jan 1, 1983·Digestive Diseases and Sciences·D Y GrahamS M Dobbs
Jul 4, 2002·The American Journal of Gastroenterology·Philip MinerSheldon Sloan
Jun 26, 2003·Alimentary Pharmacology & Therapeutics·D PantoflickovaA L Blum
Jan 18, 2006·Digestive Diseases and Sciences·Hrair P SimonianHenry P Parkman

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Citations

Jul 14, 2010·Journal of Gastroenterology and Hepatology·Takashi KawaiAkira Yamashina
Feb 6, 2009·Drugs·Marco Lazzaroni, Gabriele Bianchi Porro
Oct 1, 2009·Current Medical Research and Opinion·Neville D YeomansJørgen Naesdal
Jan 6, 2009·Current Opinion in Gastroenterology·Maggie Ham, Jonathan D Kaunitz
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Stefano PallottaSilvia Marelli

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