Rapid prototyping of three-dimensional nanocomposite hydrogel constructs: effect of silica nanofiller on swelling and solute release behaviors of the nanocomposite hydrogels

Journal of Biomedical Materials Research. Part a
Swati MishraPaul Calvert

Abstract

Three-dimensional (3D) patterning and engineering of biomaterials and biointerfaces have helped bioengineers harness the full potential of cell immobilization for different biomedical applications. However, the bioengineering of an efficient cell immobilized tool, having application in cell biology and tissue engineering, often comes into realization only when a cell friendly immobilization technique is combined with a compatible 3D patterning scheme. We have previously demonstrated the successful blue light induced photopolymerization of poly (ethyleneglycol) diacrylate (PEGDA) based hydrogels for the entrapment of Saccharomyces cerevisiae and NIH 3T3 fibroblast cells. In the present work we have modified rheology of the prepolymer solution by mixing fumed silica nanofiller in different concentrations. Here we demonstrate the rapid prototyping of cell immobilized nanocomposite hydrogels, where S. cerevisiae loaded nanofilled prepolymer solution was directly written in layer-by-layer fashion using solid free form fabrication also known as rapid prototyping technique and was cross-linked into 3D cell loaded construct via blue light induced polymerization. The swelling trend was found to be a function of silica nanofiller concent...Continue Reading

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Jun 9, 2012·Journal of Biomedical Materials Research. Part a·Swati MishraPaul Calvert

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Citations

Dec 29, 2016·Biomacromolecules·Sytze J BuwaldaWim E Hennink
Oct 27, 2018·ACS Applied Materials & Interfaces·Mihyun LeeMarcy Zenobi-Wong

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