Rapid purification and size separation of gold nanoparticles via diafiltration

Journal of the American Chemical Society
Scott F SweeneyJames E Hutchison

Abstract

Purification and size-based separation of nanoparticles remain significant challenges in the preparation of well-defined materials for fundamental studies and applications. Diafiltration shows considerable potential for the efficient and convenient purification and size separation of water-soluble nanoparticles, allowing for the removal of small-molecule impurities and for the isolation of small nanoparticles from larger nanostructures in a single process. Herein, we report studies aimed at assessing the suitability of diafiltration for (i) the purification of water-soluble thiol-stabilized 3-nm gold nanoparticles, (ii) the separation of a bimodal distribution of nanoparticles into the corresponding fractions, and (iii) the separation of a polydisperse sample into fractions of differing mean core diameter. NMR, thermogravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS) measurements demonstrate that diafiltration produces nanoparticles with a much higher degree of purity than is possible by dialysis or a combination of solvent washes, chromatography, and ultracentrifugation. UV-visible spectroscopic and transmission electron microscopic (TEM) analyses show that diafiltration offers the ability to separate nanop...Continue Reading

References

Oct 21, 1999·Journal of Structural Biology·W Jahn
Nov 28, 2001·Analytical Chemistry·B NeimanO Lev
Nov 24, 2004·Colloids and Surfaces. B, Biointerfaces·Catherine M GoodmanVincent M Rotello
Feb 17, 2005·Journal of the American Chemical Society·Gerd H WoehrleJames E Hutchison
Feb 8, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Gerd H WoehrleJames E Hutchison
Jul 21, 2006·The Journal of Physical Chemistry. B·Gregory Kalyuzhny, Royce W Murray

❮ Previous
Next ❯

Citations

Feb 18, 2009·Analytical and Bioanalytical Chemistry·Wenwan Zhong
Feb 15, 2011·Analytical and Bioanalytical Chemistry·Petr S FedotovBoris Ya Spivakov
Apr 13, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Vivek D BadwaikRajalingam Dakshinamurthy
Aug 30, 2012·Nano Letters·Mamoru Tamura, Takuya Iida
Jan 25, 2011·Nature Nanotechnology·Elisha KriegBoris Rybtchinski
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·A CentroneF Stellacci
Jul 28, 2012·Investigative Radiology·Andrew S TorresMichael E Marino
May 27, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rosina Ho WuMarilyn R Mackiewicz
Sep 25, 2007·Drug Development and Industrial Pharmacy·Gautam Dalwadi, Vivian Bruce Sunderland
Aug 31, 2010·Biomaterials·Suresh K BalasubramanianLiya E Yu
Oct 11, 2015·Talanta·Kamran DastafkanNader Sheibani
Jul 4, 2009·Bioresource Technology·Kalimuthu KalishwaralalSangiliyandi Gurunathan
Aug 27, 2014·Microbial Biotechnology·Michael KitchingEnrico Marsili
Oct 6, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Edward W ElliottJames E Hutchison
Jul 4, 2008·Annals of the New York Academy of Sciences·Tero SoukkaKatri Kuningas
Oct 27, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Zachary C KennedyJames E Hutchison
Sep 22, 2012·Human Vaccines & Immunotherapeutics·Qiang Chen, Huafang Lai
Jun 9, 2016·Scientific Reports·James D RobertsonGiuseppe Battaglia
May 19, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Edward W ElliottJames E Hutchison
Jun 17, 2014·Electrophoresis·Swagatika Dash, Swati Mohanty
Dec 13, 2016·Chemical Communications : Chem Comm·Yi ShenA B Greytak
Dec 25, 2008·Angewandte Chemie·Xiaoming SunHongjie Dai
May 15, 2009·Physical Chemistry Chemical Physics : PCCP·Vincenzo Amendola, Moreno Meneghetti
Dec 25, 2009·Chemistry : a European Journal·Zhijiang WangWei Cai
Aug 18, 2010·Lab on a Chip·Samuel M StavisMichael Gaitan

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.