Rapid quantitative T2 mapping of the prostate using three-dimensional dual echo steady state MRI at 3T

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Isabel DregelyHolden H Wu

Abstract

To develop and evaluate a rapid three-dimensional (3D) quantitative T2 mapping method for prostate cancer imaging using dual echo steady state (DESS) MRI at 3T. In simulations, DESS-T2 mapping in the presence of T1 and B1+ variations was evaluated. In a phantom and in healthy volunteers (n = 4), 3D DESS-T2 mapping was compared with a two-dimensional turbo spin echo (TSE) approach. In volunteers and a pilot patient study (n = 29), quantitative T2 in normal prostate anatomical zones and in suspected cancerous lesions was evaluated. The simulated bias for DESS-T2 was < 2% (5%) for typically observed T1 ( B1+) variations. In phantoms and in vivo, high correlation of DESS-T2 and TSE-T2 (r2  = 0.98 and 0.88, P < 0.001) was found. DESS-T2 in the normal peripheral zone and transition zone was 115 ± 26 ms and 64 ± 7 ms, respectively, in healthy volunteers and 129 ± 39 ms and 83 ± 12 ms, respectively, in patients. In suspected cancerous lesions, DESS-T2 was 72 ± 14 ms, which was significantly decreased from the normal peripheral zone (P < 0.001) but not from the transition zone. Rapid 3D T2 mapping in the entire prostate can be performed in 1 min using DESS MRI. Magn Reson Med 76:1720-1729, 2016. © 2016 International Society for Magnetic...Continue Reading

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Citations

Jul 4, 2018·Journal of Magnetic Resonance Imaging : JMRI·Isabel DregelyVicky Goh
Aug 21, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bragi SveinssonDaehyun Yoon
Oct 29, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Elisa RocciaIsabel Dregely
Apr 23, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rohini Vidya ShankarIsabel Dregely
Oct 19, 2019·Journal of Magnetic Resonance Imaging : JMRI·Zhaohuan ZhangHolden H Wu
May 21, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yaghoub FatemiHoushang Amiri
Jul 4, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Petra J van HoudtUulke A van der Heide
Nov 28, 2020·Physics in Medicine and Biology·Bragi SveinssonDaehyun Yoon
Jul 17, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Frank Zijlstra, Peter R Seevinck
Sep 19, 2021·Journal of Magnetic Resonance Imaging : JMRI·Stephan E MaierMikael Hellström

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