Rapid rates of lineage-specific gene duplication and deletion in the alpha-globin gene family

Molecular Biology and Evolution
Federico G HoffmannJay F Storz

Abstract

Phylogeny reconstructions of the globin gene families have revealed that paralogous genes within species are often more similar to one another than they are to their orthologous counterparts in closely related species. This pattern has been previously attributed to mechanisms of concerted evolution such as interparalog gene conversion that homogenize sequence variation between tandemly duplicated genes and therefore create the appearance of recent common ancestry. Here we report a comparative genomic analysis of the alpha-globin gene family in mammals that reveal a surprisingly high rate of lineage-specific gene duplication and deletion via unequal crossing-over. Results of our analysis reveal that patterns of sequence similarity between paralogous alpha-like globin genes from the same species are only partly explained by concerted evolution between preexisting gene duplicates. In a number of cases, sequence similarity between paralogous sequences from the same species is attributable to recent ancestry between the products of de novo gene duplications. As a result of this surprisingly rapid rate of gene gain and loss, many mammals possess alpha-like globin genes that have no orthologous counterparts in closely related species....Continue Reading

References

Feb 20, 1975·Nature·M GoodmanG Matsuda
Apr 11, 1975·Science·M C King, A C Wilson
Feb 1, 1990·Theoretical Population Biology·T Ohta
Feb 22, 1990·Journal of Theoretical Biology·F RodríguezJ R Medina
Feb 5, 1988·Journal of Molecular Biology·J FlintJ B Clegg
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T Nagylaki
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E A ZimmerA C Wilson
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·A D BaileyC K Shen
Apr 25, 1997·Journal of Molecular Biology·C Burge, S Karlin
May 26, 1999·FEMS Microbiology Letters·T A Tatusova, T L Madden
Apr 26, 2000·Genome Research·S SchwartzW Miller
Jun 1, 2000·Molecular Biology and Evolution·T PupkoD Graur
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·M NeiH Piontkivska
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·D WheelerR A Holland
Feb 13, 2001·Gene·T Ohta
Feb 24, 2001·Nature·W J MurphyS J O'Brien
Sep 26, 2001·Hemoglobin·T H LeD K Truong
Nov 6, 2001·Critical Reviews in Eukaryotic Gene Expression·F Recillas-Targa, S V Razin
Apr 19, 2002·Molecular Biology and Evolution·Helen PiontkivskaMasatoshi Nei
Jun 25, 2002·Systematic Biology·Hidetoshi Shimodaira
Jun 26, 2003·Nucleic Acids Research·Scott SchwartzWebb Miller
Jun 30, 2004·BMC Evolutionary Biology·Gangolf JobbKorbinian Strimmer
Jul 16, 2004·Molecular Biology and Evolution·José M Eirín-LópezJosefina Méndez
Mar 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Alejandro P Rooney, Todd J Ward
Jul 8, 2005·PLoS Biology·Sean B Carroll
Jul 13, 2005·Trends in Genetics : TIG·Morris GoodmanDerek E Wildman
Nov 16, 2005·Annual Review of Genetics·Masatoshi Nei, Alejandro P Rooney
May 16, 2006·Molecular Phylogenetics and Evolution·Juan C OpazoMorris Goodman
May 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kwan-Wood G Lam, Alec J Jeffreys
Dec 13, 2006·Genes & Genetic Systems·Gabriela AguiletaZiheng Yang
Dec 22, 2006·PloS One·Jeffery P DemuthMatthew W Hahn

❮ Previous
Next ❯

Citations

Dec 1, 2010·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Vidushi S PatelJennifer A Marshall Graves
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Juan C OpazoJay F Storz
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jay F StorzAngela Fago
Sep 11, 2012·The Journal of Biological Chemistry·Michael T GrispoJay F Storz
Jun 24, 2011·Genome Biology and Evolution·Federico G HoffmannJay F Storz
Mar 29, 2012·Genome Biology and Evolution·Giltae SongWebb Miller
Sep 11, 2008·Molecular Biology and Evolution·Federico G HoffmannJay F Storz
Apr 1, 2009·Molecular Biology and Evolution·Juan C OpazoJay F Storz
Sep 6, 2012·Molecular Biology and Evolution·Juan C OpazoFederico G Hoffmann
Sep 15, 2012·Proceedings. Biological Sciences·Fyodor A Kondrashov
Dec 5, 2012·Cold Spring Harbor Perspectives in Medicine·Ross C Hardison
Feb 5, 2011·Science·John K ColbourneJeffrey L Boore
Dec 17, 2011·Genome Génome / Conseil National De Recherches Canada·Daniel Campo, Eva García-Vázquez
Jul 30, 2011·BMC Evolutionary Biology·Giltae SongWebb Miller
Oct 7, 2010·BMC Genomics·Nicole L QuinnWilliam S Davidson
Jul 20, 2010·The Journal of Experimental Biology·Jay F StorzAngela Fago
Jan 29, 2011·The Journal of Experimental Biology·Jay F StorzHideaki Moriyama
May 13, 2014·Genome Biology and Evolution·Michael J GaudryFederico G Hoffmann
Oct 8, 2014·BMC Genomics·Mariana F NeryJuan C Opazo
Dec 17, 2014·Molecular Biology and Evolution·Juan C OpazoJay F Storz
Jun 23, 2011·PLoS Computational Biology·Nathan L NehrtMatthew W Hahn
Jun 17, 2015·Genome Biology and Evolution·Kim SchwarzeThorsten Burmester
Jan 18, 2018·Genome Biology and Evolution·Federico G HoffmannJuan C Opazo
May 11, 2011·IUBMB Life·Jay F StorzFederico G Hoffmann
Nov 18, 2020·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·João Pedro Fernandes QueirozBruno Anderson Matias Rocha
Oct 28, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naim M BautistaAngela Fago

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.