Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jens VerheyenStefan Esser

Abstract

Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Δ32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.

References

Feb 14, 2009·The New England Journal of Medicine·Gero HütterEckhard Thiel
Apr 25, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jori SymonsMonique Nijhuis
Aug 28, 2014·The New England Journal of Medicine·Lambros KordelasUNKNOWN Essen HIV AlloSCT Group
Dec 18, 2014·The New England Journal of Medicine·Jens VerheyenLambros Kordelas
Dec 18, 2014·The New England Journal of Medicine·Gero Hütter
Aug 1, 2015·Viruses·Gero HütterGeoff Symonds

❮ Previous
Next ❯

Citations

Feb 9, 2019·Current HIV/AIDS Reports·Rebecca T VeenhuisLucio Gama
Mar 6, 2019·Nature·Ravindra K GuptaEduardo Olavarria
May 17, 2019·Current HIV/AIDS Reports·William A Werbel, Christine M Durand
Feb 25, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Junpeng ZhaoLunan Wang
Nov 7, 2019·Journal of Virology·Lisa J HendersonAvindra Nath
Nov 27, 2019·Briefings in Functional Genomics·Jinyu SunXiaorong Hu
Sep 29, 2020·Scientific Reports·Bridgette J ConnellMonique Nijhuis
Jun 5, 2019·Nature Medicine·Jeremy Luban
Jan 16, 2020·Viruses·Gerlinde VansantZeger Debyser
Jan 9, 2019·Frontiers in Microbiology·Alexander G AllenBrian Wigdahl
Jun 21, 2019·JCI Insight·John M CoffinStephen H Hughes
Feb 16, 2021·The Journal of Infectious Diseases·Yijia LiJonathan Z Li
Mar 3, 2020·EBioMedicine·Prasanta K DashHoward E Gendelman
Aug 21, 2020·Current HIV Research·Edward K MainaRaphael M Lwembe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jori SymonsMonique Nijhuis
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Marie von Lilienfeld-ToalGordon Cook
© 2022 Meta ULC. All rights reserved