Rapid recovery and altered neurochemical dependence of locomotor central pattern generation following lumbar neonatal spinal cord injury

The Journal of Physiology
Mark ZüchnerJean-Luc Boulland

Abstract

Spinal compression injury targeted to the neonatal upper lumbar spinal cord, the region of highest hindlimb locomotor rhythmogenicity, leads to an initial paralysis of the hindlimbs. Behavioural recovery is evident within a few days and approaches normal function within about 3 weeks. Fictive locomotion in the isolated injured spinal cord cannot be elicited by a neurochemical cocktail containing NMDA, dopamine and serotonin 1 day post-injury, but can 3 days post-injury as readily as in the uninjured spinal cord. Low frequency coordinated rhythmic activity can be elicited in the isolated uninjured spinal cord by NMDA + dopamine (without serotonin), but not in the isolated injured spinal cord. In both the injured and uninjured spinal cord, eliciting bona fide fictive locomotion requires the additional presence of serotonin. Following incomplete compression injury in the thoracic spinal cord of neonatal mice 1 day after birth (P1), we previously reported that virtually normal hindlimb locomotor function is recovered within about 3 weeks despite substantial permanent thoracic tissue loss. Here, we asked whether similar recovery occurs following lumbar injury that impacts more directly on the locomotor central pattern generator (CPG...Continue Reading

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Citations

Dec 12, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Yawen ZhangFang Zhou
Oct 1, 2019·Current Opinion in Neurology·Anna-Sophie Hofer, Martin E Schwab
Nov 23, 2017·The Journal of Physiology·Brian J Schmidt
Jun 3, 2021·International Journal of Molecular Sciences·Jadwiga N BilchakMarie-Pascale Côté
Jul 3, 2021·Cells·Vasiliki Tsata, Daniel Wehner
Sep 1, 2021·Disease Models & Mechanisms·Mark ZüchnerJean-Luc Boulland
Aug 20, 2021·The Journal of Physiology·Marie BoulainLaurent Juvin

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