PMID: 9536444Apr 16, 1998Paper

Rapid recovery following contraction-induced injury to in situ skeletal muscles in mdx mice

Journal of Muscle Research and Cell Motility
S V Brooks

Abstract

The muscles of mdx mice lack the subsarcolemmal protein dystrophin, and as a consequence may be more susceptible to damage induced by contractions. The purpose of this study was to characterize the response of muscles in mdx mice to contraction-induced injury in situ. The hypothesis tested was that following a protocol of repeated stretches of maximally activated muscles, the magnitude of the injury is greater for muscles in mdx mice than for muscles in C57BL/10 control mice, and consequently, the muscles in mdx mice recover more slowly. Each stretch was of 20% strain relative to muscle fibre length (Lf) at 0.5 Lf s-1 and was initiated from the force plateau of an isometric contraction. The protocol consisted of a total of ten contractions, with one contraction occurring every ten seconds. The time-course of injury and recovery was determined through measurements of in situ force production at 10, 30, 45 and 60 minutes, and either 12, 24, 48 or 72 hours after the contraction protocol. The initial injury, as assessed by the decrease in force production both immediately and 60 minutes after the contraction protocol, was significantly greater for the muscles in mdx mice compared with those in control mice. Over the next three days...Continue Reading

Citations

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