Rapid Recovery of Vesicular Dopamine Levels in Methamphetamine Users in Early Abstinence

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Isabelle BoileauStephen J Kish

Abstract

We previously reported very low levels of dopamine in post-mortem striatum of chronic methamphetamine users, raising the possibility that restoration of normal dopamine levels could help in this addiction and perhaps prevent early relapse. To establish relevance of this finding to the living brain, we tested whether striatal [(11)C]-(+)-dihydrotetrabenazine binding, a vesicular monoamine transporter probe sensitive to changes in (stored) vesicular dopamine, is elevated in methamphetamine users. Chronic methamphetamine users underwent [(11)C]-(+)-dihydrotetrabenazine positron emission tomography scans during early (mean 2.6 days) and later (~10 days) abstinence. Striatal [(11)C]-(+)-dihydrotetrabenazine binding was elevated (suggesting low stored dopamine) in methamphetamine users (n=28; 2.6 days after last use) relative to controls (n=22) (+28%, p<0.0001) and correlated with severity and recency of drug use and with cognitive impairment and withdrawal symptoms. Mean [(11)C]-(+)-dihydrotetrabenazine binding levels in the subgroup of methamphetamine users who could remain abstinent ~10 days following last use (n=17) were normal at the follow-up scan. Our imaging data support post-mortem findings and suggest that chronic methamphe...Continue Reading

References

Jan 1, 1988·Journal of Psychiatric Research·R L Spitzer, J B Williams
Aug 1, 1995·Brain and Cognition·A E Taylor, J A Saint-Cyr
Dec 29, 1995·European Journal of Pharmacology·T Vander BorghtK Frey
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A KoeppeD E Kuhl
Dec 1, 1996·Annals of Neurology·K A FreyD E Kuhl
Apr 1, 1997·IEEE Transactions on Medical Imaging·M DefriseD F Newport
Feb 1, 1997·Addiction·L Topp, R P Mattick
Dec 1, 1996·NeuroImage·A A Lammertsma, S P Hume
Mar 7, 2001·The American Journal of Psychiatry·N D VolkowE N Miller
Mar 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Diana MartinezMarc Laruelle
Apr 24, 2003·Synapse·Raúl De La Fuente-FernándezA Jon Stoessl
Dec 3, 2003·Brain : a Journal of Neurology·Anna MoszczynskaStephen J Kish
Oct 6, 2004·Journal of Forensic Sciences·Kathryn S KalasinskyStephen J Kish
Sep 1, 2005·Addiction·Catherine McGregorJason M White
Mar 7, 2006·Psychopharmacology·Chris-Ellyn JohansonCharles R Schuster
Jun 27, 2006·Psychiatry Research·Pablo RusjanShitij Kapur
Jul 13, 2006·The Journal of Pharmacology and Experimental Therapeutics·John S PartillaRichard B Rothman
Jun 19, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Stephen J Kish
Sep 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Isabelle BoileauStephen J Kish
Apr 25, 2009·Synapse·Raúl de la Fuente-FernándezA Jon Stoessl
Feb 4, 2010·Nuclear Medicine and Biology·Michael R KilbournKirk A Frey
Sep 16, 2010·Addiction·Todd ZorickEdythe D London
Apr 28, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Junchao TongStephen J Kish
Jul 13, 2011·Molecular Psychiatry·G J WangJ S Fowler
Nov 15, 2011·Brain : a Journal of Neurology·Ramachandiran NandhagopalA Jon Stoessl
Dec 24, 2011·The American Journal of Psychiatry·Rajesh NarendranW Gordon Frankle
Apr 8, 2014·Neurobiology of Disease·Junchao TongStephen J Kish
Dec 10, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Andrew J LeesC Warren Olanow

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Citations

Jun 21, 2017·The Journal of Pharmacology and Experimental Therapeutics·Anna Moszczynska, Sean Patrick Callan
Dec 3, 2016·The American Journal of Drug and Alcohol Abuse·Thulasi ThiruchselvamBernard Le Foll
Jun 30, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Isabelle BoileauStephen J Kish

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