Rapid redistribution of teboroxime

The American Journal of Cardiology
H WeinsteinJ A Leppo

Abstract

Teboroxime, a new technetium-99m-labeled myocardial perfusion tracer, possesses rapid myocardial kinetics. Whereas this agent is routinely imaged after separate stress and rest injections, experimental data suggest that teboroxime may rapidly redistribute in the myocardium. Accordingly, we assessed 68 exercise teboroxime scintigrams in which immediate poststress, early delay (5 minutes) and rest images were acquired. Studies were categorized visually as ischemia, infarct or normal based on conventional stress-rest comparison. They were then evaluated for rapid teboroxime redistribution by comparing the stress and early delay images. Quantitative analysis was then performed on 537 myocardial segments. Segments were grouped as ischemia, infarct or normal based on stress-rest comparison, and the degree of normalization of stress-induced defects in the early delay images was determined for each group. Rapid teboroxime redistribution was observed in 20 of 46 scintigrams (48%) considered ischemic, and in 2 of 7 and 2 of 15 scintigrams deemed infarct and normal, respectively. The mean segmental intensity ratio (defined relative to the opposite segment) improved from 0.79 at stress to 0.88 at early delay (p < 0.005) in the group with i...Continue Reading

Citations

Jul 1, 1994·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·G JohnsonR D Okada
Mar 1, 1994·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·S T Dahlberg, J A Leppo
Jun 6, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Bing FengMichael A King
Dec 23, 1999·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·T A HollyS T Dahlberg
Jun 1, 2000·IEEE Transactions on Nuclear Science·D J KadrmasG T Gullberg
May 10, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Raymond Taillefer

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