Rapid regulatory evolution of a nonrecombining autosome linked to divergent behavioral phenotypes

Proceedings of the National Academy of Sciences of the United States of America
Dan SunSoojin V Yi

Abstract

In the white-throated sparrow (Zonotrichia albicollis), the second chromosome bears a striking resemblance to sex chromosomes. First, within each breeding pair of birds, one bird is homozygous for the standard arrangement of the chromosome (ZAL2/ZAL2) and its mate is heterozygous for a different version (ZAL2/ZAL2m). Second, recombination is profoundly suppressed between the two versions, leading to genetic differentiation between them. Third, the ZAL2m version is linked with phenotypic traits, such as bright plumage, high aggression, and low parental behavior, which are usually associated with males. These similarities to sex chromosomes suggest that the evolutionary mechanisms that shape sex chromosomes, in particular genetic degeneration of the heterogametic version due to the suppression of recombination, are likely important in this system as well. Here, we investigated patterns of protein sequence evolution and gene expression evolution between the ZAL2 and ZAL2m chromosomes by whole-genome sequencing and transcriptome analyses. Patterns of protein evolution exhibited only weak signals of genetic degeneration, and few genes harbored signatures of positive selection. We found substantial evidence of transcriptome evolution...Continue Reading

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Citations

Oct 3, 2018·Molecular Biology and Evolution·Groves DixonMark Kirkpatrick
Feb 28, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Lingzhao FangGeorge E Liu
Apr 25, 2019·Journal of Evolutionary Biology·Amaury AvrilMichel Chapuisat
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Aug 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jennifer R MerrittDonna L Maney
Aug 5, 2020·Molecular Ecology·Samuel V ArsenaultBrendan G Hunt
Sep 17, 2020·Hormones and Behavior·Donna L ManeySoojin V Yi
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Mar 20, 2021·Genome Biology and Evolution·Juanita Gutiérrez-ValenciaTanja Slotte
Jun 22, 2021·Frontiers in Genetics·Jasmine L LovelandClemens Küpper
Jun 20, 2021·Molecular Ecology·Jordan A Anderson, Jenny Tung
Dec 9, 2020·Current Biology : CB·Peri E Bolton, Christopher N Balakrishnan

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Methods Mentioned

BETA
RNA-seq

Software Mentioned

PANTHER System
LASTZ
count
ZAL2
GATK
Genome Analysis Toolkit ( GATK )
New
PAML
Hon
DESeq2

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