PMID: 2121199Oct 1, 1990Paper

Rapid resolution of ST elevation and prediction of clinical outcome in patients undergoing thrombolysis with alteplase (recombinant tissue-type plasminogen activator): results of the Israeli Study of Early Intervention in Myocardial Infarction

British Heart Journal
G I BarbashE Kaplinsky

Abstract

Alteplase (recombinant tissue-type plasminogen activator (rt-PA)) was infused within four hours of onset of symptoms in 286 patients with acute myocardial infarction. Delayed coronary angiography was performed 72 hours after admission with coronary angioplasty if indicated. Electrocardiographic monitoring was continuous during the first hour of treatment. The sum of the ST segment elevations (sigma ST) was calculated on electrocardiograms recorded at entry and an hour later. ST elevations resolved rapidly within one hour of treatment in 189 patients and persisted in 97 patients. Rapid resolution of ST elevation correlated with angiographic coronary patency as determined by coronary angiography 72 hours after admission. The patients with rapid resolution of sigma ST had significantly smaller infarcts and a better clinical outcome than the patients with persistent ST elevation. sigma ST values at entry and one hour after treatment had no additional independent predictive value. Rapid resolution of ST elevations in patients undergoing thrombolysis with alteplase was associated with a significantly smaller release of creatine kinase, better preservation of left ventricular function, lower morbidity, and less short and long term mor...Continue Reading

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Citations

Aug 18, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christoph J JensenOliver Bruder
Aug 29, 2012·Current Heart Failure Reports·Steven K WhiteJames C Moon
Sep 1, 1995·Journal of the American College of Cardiology·A R FernandezR J Myerburg
Oct 7, 1997·The American Journal of Cardiology·G M SantoroP F Fazzini
Jun 15, 1995·The American Journal of Cardiology·P A DoevendansH J Wellens
Nov 3, 2001·Journal of the American College of Cardiology·J A de Lemos, E Braunwald
Dec 10, 1999·Journal of the American College of Cardiology·S MatetzkyH Hod
Nov 4, 1998·Postgraduate Medical Journal·I R Mahy, K P Jennings
Jun 13, 2003·Current Cardiology Reports·Per JohansonMitchell W Krucoff
Aug 31, 2006·Cardiology Clinics·Shaul AtarYochai Birnbaum
Dec 15, 2005·Heart, Lung & Circulation·Yi ZhangRichmond W Jeremy
Dec 16, 1993·The American Journal of Cardiology·P KlootwijkM L Simoons
Apr 17, 2010·Journal of the American College of Cardiology·Sebastiaan C A M BekkersJohannes Waltenberger

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