Rapid response of hypercortisolism to vandetanib treatment in a patient with advanced medullary thyroid cancer and ectopic Cushing syndrome

Archives of Endocrinology and Metabolism
Fabián PitoiaGraciela Cross

Abstract

Medullary thyroid carcinoma (MTC) may rarely present with paraneoplastic syndromes. Among the most frequent ones are the appearance of diarrhea and ectopic Cushing syndrome (ECS). The ECS in the context of MTC is usually present in patients with distant metastatic disease. The use of drugs such as ketoconazole, metyrapone, somatostatin analogs and etomidate have been ineffective alternatives to control hypercortisolism in these patients. Bilateral adrenalectomy is often required to manage this situation. Recently, the use of tyrosine kinase inhibitors has been shown to be a useful tool to achieve eucortisolism in patients with metastatic MTC and ECS. We present a patient with sporadic advanced persistent and progressive MTC with lymph node and liver metastases, which after 16 years of follow-up developed an ECS. After one month of 300 mg/day vandetanib treatment, a biochemical and clinical response of the ECS was achieved but it did not result in significant reduction of tumor burden. However the patient reached criteria for stable disease according to response evaluation criteria in solid tumors (RECIST 1.1) after 8 months of follow-up.

References

May 26, 2005·The Journal of Clinical Endocrinology and Metabolism·Ioannis IliasLynnette K Nieman
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·Sandrine Laboureau-Soares BarbosaUNKNOWN Groupe d'Etude des Tumeurs Endocrines
Nov 25, 2006·Thyroid : Official Journal of the American Thyroid Association·Jan Willem B de GrootThera P Links
Aug 13, 2008·Hormones : International Journal of Endocrinology and Metabolism·Alexandra ChrisoulidouIraklis Vainas
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
Oct 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Samuel A WellsMartin J Schlumberger
Feb 9, 2012·International Journal of Molecular Sciences·Lucieli CeolinAna Luiza Maia
Apr 16, 2013·Endocrine·Cosimo DuranteSebastiano Filetti
Aug 9, 2013·The New England Journal of Medicine·Camille BaudryLionel Groussin
Mar 13, 2014·The Journal of Clinical Endocrinology and Metabolism·A A NellaC A Stratakis
Apr 18, 2014·Endocrinology and Metabolism·Hong Seok ChoiYun Hyi Ku

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Citations

May 22, 2016·Endocrine-related Cancer·David ViolaRossella Elisei
Jun 15, 2016·Expert Opinion on Drug Safety·Venessa H M TsangDiana L Learoyd
Oct 19, 2016·Expert Review of Anticancer Therapy·Poupak FallahiAlessandro Antonelli
Sep 4, 2015·Archives of Endocrinology and Metabolism·Ana O Hoff
May 4, 2016·Journal of Investigative Medicine High Impact Case Reports·Leslee N MathenyHoward B A Baum
Nov 18, 2016·Endocrinology, Diabetes & Metabolism Case Reports·Hashem BseisoSimona Grozinsky-Glasberg
Jan 11, 2017·Thyroid : Official Journal of the American Thyroid Association·Anne-Cécile PaepegaeyLionel Groussin

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