Rapid response to fluoxetine in women with premenstrual dysphoric disorder.

Depression and Anxiety
Emma M SteinbergPeter J Schmidt

Abstract

Selective serotonin reuptake inhibitors (SRIs) relieve irritability within days in women with premenstrual dysphoric disorder (PMDD); however, the effects on other affective symptoms in PMDD remain to be demonstrated. We performed hourly ratings in women with PMDD to test the specificity of the therapeutic effects of SRIs and to determine whether the kinetics of these effects differ from those of the symptom offset accompanying menses. Twelve women with PMDD received fluoxetine (20 mg daily) during the luteal phase of the menstrual cycle. Twelve other women with PMDD received no treatment. Outcome measures included a visual analogue scale completed hourly before and after either the start of SRIs or at menses-onset in the untreated women and the premenstrual tension syndrome (PMTS) scale completed daily. Data were analyzed by ANOVA-R. Hourly VAS scores significantly improved after SRI in irritability as well as sadness, anxiety, and mood swings. Compared with the symptomatic pretreatment baseline, PMTS scores significantly improved on the second day after the start of SRI (p < .01). An identical time course of symptom improvement occurred after both SRI and menses-onset. These data document that the rapid response to SRI was no...Continue Reading

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Citations

Aug 21, 2013·Nursing for Women's Health·Kelli Kelderhouse, Julie Smith Taylor
Jul 22, 2015·Human Psychopharmacology·Christine JacksonSamantha Meltzer-Brody
Sep 26, 2015·Journal of Affective Disorders·Renske C BosmanMarije aan het Rot
Sep 18, 2015·Current Psychiatry Reports·Liisa Hantsoo, C Neill Epperson
May 29, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Amanda P Borrow, Nicole M Cameron
Apr 14, 2015·Psychological Medicine·L P CapitãoC J Harmer
Dec 17, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Adam J DevallThelma A Lovick
Feb 20, 2014·International Journal of Psychiatry in Medicine·Chih-Hung KoJu-Yu Yen
Jan 22, 2019·Translational Psychiatry·Liliana P CapitãoCatherine J Harmer
Sep 4, 2020·Neuroscience and Biobehavioral Reviews·M W L MorssinkhofB F P Broekman

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