Rapid reversal of chondroitin sulfate proteoglycan associated staining in subcompartments of mouse neostriatum during the emergence of behaviour.

PloS One
Hyunchul LeeAtomu Sawatari

Abstract

The neostriatum, the mouse homologue of the primate caudate/putamen, is the input nucleus for the basal ganglia, receiving both cortical and dopaminergic input to each of its sub-compartments, the striosomes and matrix. The coordinated activation of corticostriatal pathways is considered vital for motor and cognitive abilities, yet the mechanisms which underlie the generation of these circuits are unknown. The early and specific targeting of striatal subcompartments by both corticostriatal and nigrostriatal terminals suggests activity-independent mechanisms, such as axon guidance cues, may play a role in this process. Candidates include the chondroitin sulfate proteoglycan (CSPG) family of glycoproteins which have roles not only in axon guidance, but also in the maturation and stability of neural circuits where they are expressed in lattice-like perineuronal nets (PNNs). The expression of CSPG-associated structures and PNNs with respect to neostriatal subcompartments has been examined qualitatively and quantitatively using double-labelling for Wisteria floribunda agglutinin (WFA), and the mu-opioid receptor (muOR), a marker for striosomes, at six postnatal ages in mice. We find that at the earliest ages (postnatal day (P)4 and ...Continue Reading

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Citations

Mar 20, 2012·PloS One·Hyunchul LeeAtomu Sawatari
Jul 25, 2019·Frontiers in Neuroscience·Sandeep KumarSoumya Iyengar
Mar 31, 2018·Frontiers in Behavioral Neuroscience·Darius Rountree-HarrisonAtomu Sawatari
Jan 7, 2022·Movement Disorders : Official Journal of the Movement Disorder Society·Dhananjay YellajoshyulaWilliam T Dauer

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Methods Mentioned

BETA
fluorescence imaging

Software Mentioned

Neurolucida System

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