Rapid review protocol: Zinc for the prevention or treatment of COVID-19 and other coronavirus-related respiratory tract infections

Integrative Medicine Research
Jennifer HunterStephen Leeder

Abstract

The global COVID-19 pandemic has prompted an urgent search for effective interventions. SARS-CoV-2 mortality/morbidity risk increases with age and for those chronic disease co-morbidities, both of which are associated with lower zinc status, as is the risk of infection. Rapid review methods will be applied to a systematic review of zinc for the prevention or treatment of SARS-CoV-2 and viral respiratory tract infections in humans. Included are published studies reporting randomised and quasi-randomised controlled trials that compare zinc intervention to placebo and/or other comparator interventions. English and Chinese language databases will be searched for primary studies of viral respiratory tract infections and clinical trial registries for SARS-CoV-2 infections. Due to concerns about indirectness, studies evaluating non-SARS-CoV-2 coronavirus infections will be rated down by one level, and non-specific or confirmed non-coronavirus viral infections will be rated down by two levels. Review constraints include (1) using Google translate when screening articles published in languages other than English or Chinese and limited translation (2) following calibration, only one reviewer will screen articles, extract data, appraise q...Continue Reading

Citations

Jul 7, 2020·International Journal of Molecular Medicine·Felician StancioiuAristidis Tsatsakis
Jul 17, 2020·British Journal of Pharmacology·Urszula DoboszewskaKatarzyna Młyniec
Mar 7, 2021·Biomedicines·Math P CuajungcoMarcelo E Tolmasky
Mar 23, 2021·Medicine in Drug Discovery·Nikky GoelSunil Kumar Khare
Apr 18, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Raymond Chee Seong SeetMikael Hartman

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Methods Mentioned

BETA
PCR

Software Mentioned

Cochrane Rapid Reviews Methods Group
Cochrane RoB
Google Translate
RevMan
Cochrane Risk of Bias
EndNote
R

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