Rapid screening and identification of chemical hazards in surface and drinking water using high resolution mass spectrometry and a case-control filter

Chemosphere
Sarit L KaserzonMaria Jose Gomez Ramos

Abstract

Access to clean, safe drinking water poses a serious challenge to regulators, and requires analytical strategies capable of rapid screening and identification of potentially hazardous chemicals, specifically in situations when threats to water quality or security require rapid investigations and potential response. This study describes a fast and efficient chemical hazard screening strategy for characterising trace levels of polar organic contaminants in water matrices, based on liquid chromatography high resolution mass spectrometry with post-acquisition 'case-control' data processing. This method allowed for a rapid response time of less than 24 h for the screening of target, suspect and non-target unknown chemicals via direct injection analysis, and a second, more sensitive analysis option requiring sample pre-concentration. The method was validated by fortifying samples with a range of pesticides, pharmaceuticals and personal care products (n = 46); with >90% of target compounds positively screened in samples at 1 ng mL(-1), and 46% at 0.1 ng mL(-1) when analysed via direct injection. To simulate a contamination event samples were fortified with compounds not present in the commercial library (designated 'non-target compoun...Continue Reading

Citations

Jan 18, 2019·Annual Review of Food Science and Technology·Bing ShaoYongning Wu
Mar 20, 2021·Analytica Chimica Acta·M Hernández-MesaG Dervilly
Apr 30, 2021·Analytical Methods : Advancing Methods and Applications·B González-GayaO Zuloaga
May 22, 2018·Environmental Science & Technology·Pablo Gago-FerreroLutz Ahrens

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