Rapid Screening and Structural Characterization of Antioxidants from the Extract of Selaginella doederleinii Hieron with DPPH-UPLC-Q-TOF/MS Method

International Journal of Analytical Chemistry
Gang WangHang Song

Abstract

2,2-Diphenyl-1-picrylhydrazyl-ultra-high performance liquid chromatography-Q-time-of-flight mass spectrometry (DPPH-UPLC-Q-TOF/MS), as a rapid and efficient means, now was used for the first time to screen antioxidants from Selaginella doederleinii. The nine biflavone compounds were screened as potential antioxidants. The biflavones were structurally identified and divided into the three types, that is, amentoflavone-type, robustaflavone-type, and hinokiflavone-type biflavonoids. Among the compounds bilobetin (3) and putraflavone (8) were found from Selaginella doederleinii for the first time and others including amentoflavone (1), robustaflavone (2), 4'-methoxy robustaflavone (4), podocarpusflavone A (5), hinokiflavone (6), ginkgetin (7), and heveaflavone (9) were identified previously in the plant. Moreover, nine biflavones possessed a good antioxidant activity via their DPPH free radical scavenging. It demonstrates that DPPH-UPLC-Q-TOF/MS exhibits strong capacity in separation and identification for small molecule. The method is suitable for rapid screening of antioxidants without the need for complicated systems and additional instruments.

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Citations

Feb 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hong YaoXinhua Lin
Apr 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dan LiGang Wang
Nov 16, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valeria BaldanStefano Dall'Acqua
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Lanlan ShanYubo Li
Dec 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yongmei JiangGang Wang
Dec 10, 2020·Planta medica·Fernanda Priscila Santos ReginaldoRaquel Brandt Giordani
Dec 29, 2020·Natural Product Research·Heba A S El-NasharAbdel Nasser B Singab
Aug 14, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Muhammad AdnanZeliha Selamoglu
Sep 27, 2017··Gang WangTian-Qing Gan

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