Rapid screening test for tuberculosis using a 38-kDa antigen from Mycobacterium tuberculosis

Journal of Clinical Laboratory Analysis
D M Rosales-BorjasL Ortiz-Ortiz

Abstract

A screening test for the diagnosis of tuberculosis by immunodot (IDt) is described, using an antigen of Mycobacterium tuberculosis, namely, a 38-kDa glycoprotein which has shown great specificity in previous serologic analyses. The test was used to examine 28 sera from patients with lung tuberculosis. Of these, 85% were positive by micro-ELISA and by the IDt test herein described. Control sera from healthy subjects (n = 20) gave negative results for ELISA and for IDt, which indicates that the screening test is highly specific. The test is easy to handle and requires no equipment and is therefore particularly useful for field studies.

References

Apr 1, 1979·Infection and Immunity·T M DanielF T Bhe
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Nov 1, 1988·Journal of Clinical Microbiology·P S JackettJ Ivanyi
Jan 1, 1980·Journal of Immunological Methods·Z ReggiardoL Schnaper
Jan 1, 1987·Immunology Today·D B YoungJ R Lamb

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Citations

Nov 1, 2011·Nucleic Acids Research·Aadil H BhatAlka Rao
Jun 23, 2006·Journal of Clinical Pharmacy and Therapeutics·G WyrobiecJ Kurek
Oct 19, 2007·FEMS Immunology and Medical Microbiology·Raj Kumar Verma, Amita Jain
Sep 21, 2011·Tuberculosis·Juraj Ivanyi

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