Rapid, Self-driven Liquid Mixing on Open-Surface Microfluidic Platforms

Scientific Reports
Jared M MorrissetteConstantine M Megaridis

Abstract

Self-driven surface micromixers (SDSM) relying on patterned-wettability technology provide an elegant solution for low-cost, point-of-care (POC) devices and lab-on-a-chip (LOC) applications. We present a SDSM fabricated by strategically patterning three wettable wedge-shaped tracks onto a non-wettable, flat surface. This SDSM operates by harnessing the wettability contrast and the geometry of the patterns to promote mixing of small liquid volumes (µL droplets) through a combination of coalescence and Laplace pressure-driven flow. Liquid droplets dispensed on two juxtaposed branches are transported to a coalescence station, where they merge after the accumulated volumes exceed a threshold. Further mixing occurs during capillary-driven, advective transport of the combined liquid over the third wettable track. Planar, non-wettable "islands" of different shapes are also laid on this third track to alter the flow in such a way that mixing is augmented. Several SDSM designs, each with a unique combination of island shapes and positions, are tested, providing a greater understanding of the different mixing regimes on these surfaces. The study offers design insights for developing low-cost surface microfluidic mixing devices on open su...Continue Reading

References

Mar 12, 2003·Advanced Drug Delivery Reviews·Bernhard H WeiglCatherine R Cabrera
Feb 24, 2005·Lab on a Chip·Zeno GuttenbergAchim Wixforth
Jul 28, 2006·Nature·George M Whitesides
Aug 24, 2007·Lab on a Chip·Stefan Haeberle, Roland Zengerle
May 24, 2008·Analytical Chemistry·Jonathan WestAndreas Manz
Dec 17, 2009·Analytical Chemistry·Andres W MartinezEmanuel Carrilho
Feb 4, 2010·Lab on a Chip·Zhihong NieGeorge M Whitesides
Jan 21, 2011·Analytical Chemistry·Jacqui L DelaneyWei Shen
Aug 2, 2011·Nature Medicine·Curtis D ChinSamuel K Sia
Dec 30, 2011·Journal of Colloid and Interface Science·Mengjin YangJung-Kun Lee
Feb 22, 2012·Lab on a Chip·Curtis D ChinSamuel K Sia
Jul 14, 2012·Reports on Progress in Physics·Ralf SeemannStephan Herminghaus
Nov 3, 2012·Lab on a Chip·Thomas M SchutziusConstantine M Megaridis
May 9, 2013·Lab on a Chip·Ali Kemal YetisenChristopher R Lowe
Jan 15, 2014·Analytica Chimica Acta·Samir A BhaktaEmanuel Carrilho
Jul 6, 2014·ACS Applied Materials & Interfaces·Joseph E MatesConstantine M Megaridis
Dec 4, 2015·Biomicrofluidics·Marcus LehmannKeith B Neeves
Dec 3, 2016·Scientific Reports·Shang-Chi LinChao-Min Cheng

❮ Previous
Next ❯

Citations

Nov 7, 2019·Polymers·Lizbeth O Prieto-LópezJiaxi Cui
Jun 2, 2020·Biomicrofluidics·Ana Daysi Ruvalcaba-CardenasFrancisco J Tovar-Lopez
Mar 27, 2021·ACS Applied Materials & Interfaces·Yiliang LiXiufang Wen
Sep 22, 2020·ACS Omega·Subhashis Patari, Pallab Sinha Mahapatra
Jan 30, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Souvick ChatterjeeConstantine M Megaridis
Sep 19, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·S DhimanA K Sen
Feb 19, 2020·ACS Applied Materials & Interfaces·Ming LiuShaohua Chen
Jan 13, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Uddalok SenConstantine M Megaridis
Jun 7, 2018·The Journal of Physical Chemistry. a·Tamás Ditrói, Gábor Lente
Jul 14, 2020·The Journal of Physical Chemistry. B·Ming LiuShaohua Chen
Aug 19, 2020·ACS Nano·Christos StamatopoulosDimos Poulikakos
Sep 16, 2021·ACS Applied Materials & Interfaces·Mohamad Jafari GukehConstantine M Megaridis

❮ Previous
Next ❯

Methods Mentioned

BETA
biosensor
chips

Software Mentioned

JMP®

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.