PMID: 9150299Apr 1, 1997Paper

Rapid sprouting of sympathetic axons in dorsal root ganglia of rats with a chronic constriction injury

Pain
M S Ramer, M A Bisby

Abstract

We compared the time-course of sympathetic nerve sprouting into the L4-6 dorsal root ganglia (DRG) of adult rats following a chronic constriction injury (CCI) made on the sciatic nerve, or following sciatic nerve transection at the same site. We also tested the rats for changes in threshold for withdrawal from mechanical and thermal stimuli delivered to the hindpaws. We found sympathetic sprouting in DRG by 4 days following CCI, paralleling the decreases in mechanosensory threshold and preceding changes in thermal thresholds. However, with sciatic nerve transection, sympathetic sprouting was not detectable until 14 days after nerve injury. Thus, after CCI, sympathetic sprouting occurs with a sufficiently rapid time-course for it to play a role in the genesis of neuropathic pain. We suggest that the more rapid sprouting seen after CCI than after resection is due to the availability of products of Wallerian degeneration, including nerve growth factor, to both spared and regenerating axons following CCI, but not following resection.

References

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Citations

Jun 23, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Miho SekiguchiShin-Ichi Kikuchi
Jun 1, 2013·Cell Biochemistry and Biophysics·Louis S Premkumar, Reddy M Pabbidi
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Linda S Sorkin, Tony L Yaksh
Apr 13, 1999·Trends in Neurosciences·M KoltzenburgS B McMahon
Jun 19, 2001·Progress in Neurobiology·P M DunnG Burnstock
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jan 1, 1997·European Journal of Pain : EJP·P ShortlandC Molander
Nov 28, 2001·Journal of Neuroendocrinology·G Blackburn-Munro, R E Blackburn-Munro
Dec 7, 2006·Pain Practice : the Official Journal of World Institute of Pain·Jin Mo Chung, Kyungsoon Chung
Dec 7, 2006·Pain Practice : the Official Journal of World Institute of Pain·Phillip S SizerOmer Matthijs
Jan 20, 2009·Human Reproduction·Guoyun WangIan S Fraser
Jul 20, 2002·Regional Anesthesia and Pain Medicine·Quinn Hogan
Oct 19, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Guohua ZhangKaren J Berkley
Jul 23, 2011·Anesthesia and Analgesia·Hyung Seok YooChul Joong Lee
Oct 13, 2006·Archives of Histology and Cytology·Hideki TsuyoshiShigeki Hirano
Jul 17, 2001·Journal of Neurosurgery·H A Wilkinson, A S Chan
Jun 11, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Cesar R Carcamo
Jun 19, 2013·Journal of Neuropathology and Experimental Neurology·Annina B SchmidElspeth M McLachlan
Feb 12, 2008·The Journal of Pain : Official Journal of the American Pain Society·Dimitris N Xanthos, Terence J Coderre

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