Rapid steroid withdrawal in hepatitis C virus-positive kidney transplant recipients

Clinical Transplantation
Enver AkalinJonathan S Bromberg

Abstract

The effects of rapid steroid withdrawal (SW) on kidney transplantation (KT) outcome were investigated in 12 HCV+ patients in a prospective cohort study. These results were compared with 17 HCV+ patients who received KT in the prior 2 yr and treated with a standard prednisone taper protocol. SW patients received only 6 d of steroid treatment after transplantation. Eleven received Thymoglobulin and one Basiliximab induction treatment along with a calcineurin inhibitor and mycophenolate mofetil. Patient and graft survival was 92% in SW group (median follow-up 12 months, range 6-17), and 92 and 82% in the historic control group respectively (median follow-up 21 months, range 11-27). In the SW and control group, acute rejection rates were 9 and 18%, and mean creatinine levels at last follow-up 1.30 +/- 0.36 and 1.68 +/- 0.58 mg/dL respectively. Only two SW patients had an increase in liver function tests during follow-up (18%), compared with six patients in the control group (43%). This study demonstrates that rapid SW is safe for HCV+ KT recipients, without an increase in acute rejection episodes or liver function abnormalities in the short term.

References

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Citations

Jul 15, 2011·International Journal of Nephrology·Marco CarboneJames Neuberger
May 24, 2011·International Journal of Nephrology·Ignatius Y S TangEnrico Benedetti
Jul 25, 2009·Clinical Transplantation·Muhammad A RafiqEnver Akalin
Jul 28, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R D Bloom, J R Lake
Jun 9, 2012·The Mount Sinai Journal of Medicine, New York·Susan M Lerner
Apr 14, 2010·Current Opinion in Organ Transplantation·Haris PapafragkakisEnver Akalin
May 6, 2015·World Journal of Hepatology·Digdem Ozer EtikAhmet Sedat Boyacioglu
Feb 21, 2008·The International Journal of Artificial Organs·A MangiaUNKNOWN Italian Association for The Study of The Liver (A.I.S.F)

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