Rapid subcutaneous IgG replacement therapy at home for pregnant immunodeficient women

Journal of Clinical Immunology
A GardulfR Gustafson

Abstract

The use of slow or rapid, subcutaneous, IgG (SCIG) infusions in pregnant women with primary antibody deficiencies has been described earlier, though only in single-case reports. In this study, we have evaluated the effect of rapid, SCIG infusions during 11 pregnancies in nine women [six women with common variable immunodeficiency (CVID), two with IgG-subclass deficiencies, and one with combined IgA and IgG2 deficiency]. The weekly infusions were given by the women themselves at a dose of 100 mg/kg/week throughout the pregnancy. No adverse systemic reactions or pronounced, local tissue reactions were recorded during or after the more than 400 infusions. The 11 babies were healthy and were born after 38-42 weeks of uneventful gestation. The concentrations of maternal S-IgG at the time of delivery in the four women with CVID ranged from 6.0 to 8.3 g/L, with cord/maternal S-IgG ratios of 1.0-1.5. The IgG subclasses were transferred to the infants. The SCIG home-therapy regime was greatly appreciated by the women.

Citations

Apr 28, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·A L MansonN Cooper
Oct 16, 2013·Current Opinion in Allergy and Clinical Immunology·Helen Chapel, Ann Gardulf
Aug 19, 2015·Journal of Clinical Immunology·Pavlina KralickovaJiri Litzman
Feb 18, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Patricia PalmeiraMagda M S Carneiro-Sampaio
Jan 12, 2012·Clinical & Developmental Immunology·Patricia PalmeiraMagda Carneiro-Sampaio
Apr 4, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Ann Gardulf
Dec 24, 2010·Orvosi hetilap·Vera Gulácsy, László Maródi
Apr 27, 2017·Einstein·Ekaterini Simões GoudourisWilma Carvalho Neves Forte
May 19, 2010·Expert Review of Clinical Immunology·Drahomíra Detková, Teresa Español
Mar 13, 2014·American Journal of Reproductive Immunology : AJRI·Rocio Ramos-MedinaSilvia Sánchez-Ramón
Aug 2, 2006·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Jane Kirmse
Sep 15, 2005·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Akhilesh ChoukseyMelvin Berger

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