PMID: 108686Jan 1, 1979

Rapid substitution procedure for intravenous drug self-administration studies in rhesus monkeys

Pharmacology, Biochemistry, and Behavior
T G Aigner, R L Balster

Abstract

Rhesus monkeys were trained to press a lever one hundred times (FR 100) to obtain either a food pellet or an intravenous drug injection. Two daily experimental sessions, one in the morning and one in the afternoon, were divided into three 15 minute periods each. In Periods 1 and 3 lever pressing behavior was maintained by the delivery of food. Period 2 lever pressing was maintained by the intravenous injection of a drug solution. The drug available each day followed a four day sequence of cocaine (30 microgram/kg/injection), saline (1.0 ml/injection), cocaine, and test compound. This four day sequence was repeated to test a series of 16 psychoactive compounds at two doses each. These drugs were compared to saline for their ability to maintain Period 2 responding during the afternoon session. Morphine, oxymorphone, codeine, pentazocine, d-amphetamine and methylphenidate all maintained responding at rates significantly greater than for saline. Cyclazocine, naloxone, levallorphan, scopolamine, chlorpromazine, fenfluramine, and (+/-)-9-nor-9-alpha-hydroxy-hexahydrocannabinol (alpha-HHC) did not maintain responding during Period 2. The results with procaine, beta-HHC and nalorphine were considered equivocal. The authors suggest the ...Continue Reading

References

Mar 1, 1977·Pharmacology, Biochemistry, and Behavior·R D Ford, R L Balster
Jan 1, 1975·Annual Review of Psychology·W H McGlothlin
Apr 1, 1973·The Journal of Pharmacy and Pharmacology·J C CradockA M Guarino
Jan 1, 1973·Psychopharmacologia·F Hoffmeister, W Wuttke
Jan 1, 1969·Psychopharmacologia·G DeneauM H Seevers
Jan 1, 1968·Psychopharmacologia·R Pickens, W C Harris
Apr 29, 1998·Trends in Pharmacological Sciences·S D BryantL H Lazarus

Citations

Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·A M Davies, L A Parker
Jan 1, 1996·Pharmacology, Biochemistry, and Behavior·D Marona-LewickaD E Nichols
Jan 1, 1983·Social Science & Medicine·J G KennedyE Cooney
Aug 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·K W LockeR L Balster
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·Scott H KollinsC R Rush
Nov 3, 2005·Journal of Child and Adolescent Psychopharmacology·Emily MacDonald Fredericks, Scott H Kollins
Nov 3, 2010·Neuroscience and Biobehavioral Reviews·Eoin C O'ConnorAndy N Mead

Related Concepts

Metazoa
Anthropoidea
Intravenous Injections
Macaca mulatta
Reinforcement Schedule
Self Administration

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