Rapid synthesis of [18F]FDG without an evaporation step using an ionic liquid

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Hyung Woo KimMyung Chul Lee

Abstract

In this study, we describe a new 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) synthesis without a distillation step. This involves fluorinating in an ionic liquid-containing medium. A test for the effective elution of [18F]fluoride from the anion exchange resin showed the proper selection of the base and the required eluant composition, which is an essential requirement for the automation of [18F]FDG synthesis. An 18F-labeling study by nucleophilic substitution showed that the major factors controlling the yield were the temperature and the reaction medium composition. The 18F-fluorination proceeded with a labeling efficiency of 74.6+/-7.4% (n=8) for optimized conditions. Alkaline hydrolysis and purification carried out in the liquid phase provided a final decay-corrected [18F]FDG yield of 59.1+/-5.1% (n=3), a radiochemical purity of 91.9+/-3.7% (n=3), and a reaction time of 13 min. Alkaline hydrolysis and purification carried out in the solid phase provided a final decay-corrected [18F]FDG yield of 48.8+/-6.0% (n=3), a radiochemical purity of 96.0+/-4% (n=3), and a reaction time of 19 min. The rapid and straightforward synthesis of [18F]FDG can be achieved by eliminating all evaporation steps, which is made possible by the use o...Continue Reading

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Citations

Jun 15, 2010·Bioconjugate Chemistry·William J McBrideDavid M Goldenberg
Jan 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Pei Yuin KengR Michael van Dam
Jun 8, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Ping HeStephen J Archibald
Apr 1, 2010·Nuclear Medicine and Molecular Imaging·Dong Wook KimMyung-Hee Sohn
Jan 12, 2016·Chemical Reviews·Sean PreshlockVéronique Gouverneur
Jul 11, 2006·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·K Hamacher, H H Coenen
Nov 7, 2008·Angewandte Chemie·Philip W MillerAntony D Gee
May 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·William J McBrideDavid M Goldenberg
Apr 23, 2008·Chemical Reviews·Simon M AmetameyPius August Schubiger

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