Rapid target allopurinol concentrations in the hypoxic fetus after maternal administration during labour

Archives of Disease in Childhood. Fetal and Neonatal Edition
Joepe J KaandorpALLO-trial Study Group

Abstract

Perinatal hypoxia-induced free radical formation is an important cause of hypoxic-ischaemic encephalopathy and subsequent neurodevelopmental disabilities. Allopurinol reduces the formation of free radicals, which potentially limits hypoxia-induced brain damage. We investigated placental transfer and safety of allopurinol after maternal allopurinol treatment during labour to evaluate its potential role as a neuroprotective agent in suspected fetal hypoxia. We used data from a randomised, double-blind multicentre trial comparing maternal allopurinol versus placebo in case of imminent fetal hypoxia (NCT00189007). We studied 58 women in labour at term, with suspected fetal hypoxia prompting immediate delivery, in the intervention arm of the study. Delivery rooms of 11 Dutch hospitals. 500 mg allopurinol, intravenously to the mother, immediately prior to delivery. Drug disposition (maternal plasma concentrations, cord blood concentrations) and drug safety (maternal and fetal adverse events). Within 5 min after the end of maternal allopurinol infusion, target plasma concentrations of allopurinol of ≥2 mg/L were present in cord blood. Of all analysed cord blood samples, 95% (52/55) had a target allopurinol plasma concentration at the ...Continue Reading

Associated Clinical Trials

Sep 16, 2005·dr. M.J.N.L. Benders

References

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Nov 22, 2011·Archives of Disease in Childhood. Fetal and Neonatal Edition·Joepe J KaandorpManon J N L Benders
Feb 14, 2012·The Journal of Pediatrics·Nicola J RobertsonCarina Mallard
Mar 2, 2012·Neuroendocrinology·S L MillerD W Walker

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Citations

Sep 22, 2015·International Journal of Molecular Sciences·Brandon J DixonJohn H Zhang
Apr 2, 2015·Current Opinion in Anaesthesiology·Katherine Louise Shea, Arvind Palanisamy
Feb 17, 2015·Oxidative Medicine and Cellular Longevity·Maria Luisa TatarannoGiuseppe Buonocore
Sep 23, 2020·American Journal of Perinatology·Tania Siahanidou, Christina Spiliopoulou
Dec 8, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Xianlun Xu, Hao Yu

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