Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice.

Proceedings of the National Academy of Sciences of the United States of America
Ailin BaiJianzhu Chen

Abstract

To study T cell responses to tumors in an autochthonous model, we expressed a CD8 T cell epitope SIYRYYGL (SIY) in the prostate of transgenic adenocarcinoma (TRAMP) mice (referred to as TRP-SIY), which spontaneously develop prostate cancer. Naïve SIY-specific CD8 T cells adoptively transferred into TRP-SIY mice became tolerized in the prostate draining lymph nodes. Vaccination of TRP-SIY mice intranasally with influenza virus that expresses the SIY epitope resulted in generation of SIY-specific effector T cells in the lung-draining lymph nodes. These effector T cells expressed TNFalpha and IFNgamma, eliminated SIY peptide-loaded target cells in vivo, and infiltrated prostate tumors, where they rapidly lost the ability to produce effector cytokines. A population of these T cells persisted in prostate tumors but not in lymphoid organs and could be induced to re-express effector functions following cytokine treatment in vitro. These findings suggest that T cells of a given clone can be activated and tolerized simultaneously in different microenvironments of the same host and that effector T cells are rapidly tolerized in the tumors. Our model provides a system to study T cell-tumor interactions in detail and to test the efficacy o...Continue Reading

References

Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·N M GreenbergJ M Rosen
Jul 1, 1994·Cancer Immunology, Immunotherapy : CII·T L Whiteside, G Parmiani
Oct 1, 1995·Current Opinion in Immunology·J P AllisonD R Leach
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·A F OchsenbeinR M Zinkernagel
Mar 13, 2001·Annual Review of Immunology·W R Heath, F R Carbone
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·X F BaiY Liu
Feb 8, 2002·Cell·Terry Van Dyke, Tyler Jacks
Jul 3, 2002·Nature Reviews. Cancer·Stefan Stevanovic
Apr 12, 2003·Microbes and Infection·Jianzhu ChenDavid M Kranz
Sep 3, 2003·Nature Reviews. Cancer·Mark E Dudley, Steven A Rosenberg
Nov 25, 2003·Current Opinion in Immunology·Michael T SpiottoHans Schreiber
Mar 17, 2004·Current Opinion in Immunology·Suzanne Ostrand-Rosenberg
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael A LymanLinda A Sherman
Jul 13, 2004·Science·Joseph N Blattman, Philip D Greenberg
Sep 2, 2004·Nature Medicine·Steven A RosenbergNicholas P Restifo
Dec 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mei-Ling ChenKhashayarsha Khazaie
Jul 22, 2005·Nature Reviews. Cancer·Andrew J G SimpsonLloyd J Old
Sep 2, 2005·Nature·Gerald Willimsky, Thomas Blankenstein
Mar 7, 2006·Current Pharmaceutical Design·R Jeffrey KarnesEugene D Kwon
Nov 30, 2006·Annual Review of Immunology·Ann M LeenAaron E Foster
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael J AndersonArthur A Hurwitz
Feb 20, 2007·Current Opinion in Immunology·Helen Y Wang, Rong-Fu Wang
Jul 31, 2007·Seminars in Cancer Biology·Thomas Blankenstein
Dec 7, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yukiko KiniwaRong-Fu Wang
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ching-Hung ShenJianzhu Chen

❮ Previous
Next ❯

Citations

Jan 22, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Michail Sitkovsky, Akio Ohta
Feb 15, 2012·Cancer Immunology, Immunotherapy : CII·Nicolò Rigamonti, Matteo Bellone
Jun 15, 2011·Cellular & Molecular Immunology·Mobolaji O OlurindeJianzhu Chen
Mar 12, 2010·Nature·Massimo AmmiranteMichael Karin
Jul 24, 2010·Nature Reviews. Immunology·Charles G Drake
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Steven A Rosenberg
Jun 30, 2009·Journal of Immunotherapy·Andrew G BrandmaierChristopher E Touloukian
Jan 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexei ShirAlexander Levitzki
Jun 28, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kenneth F MayPhilip W Kantoff
Sep 11, 2013·The Journal of Clinical Investigation·Gang LiuJennifer D Wu
May 19, 2012·Biomaterials·Matthias T StephanDarrell J Irvine
Mar 30, 2010·Immunology Letters·Jason BrayerEduardo M Sotomayor
Nov 26, 2010·The Mount Sinai Journal of Medicine, New York·Joohee Sul, Howard A Fine
Feb 16, 2010·The Urologic Clinics of North America·Charles G Drake
Apr 12, 2016·Frontiers in Immunology·Akio Ohta
Aug 12, 2015·Prostate Cancer and Prostatic Diseases·A M MartinC G Drake
Apr 9, 2016·Oncoimmunology·David C BinderDerek A Wainwright
Jun 5, 2013·Oncoimmunology·Nathalie Wathelet, Muriel Moser
Jun 23, 2009·Current Opinion in Pharmacology·Akio Ohta, Michail Sitkovsky
May 29, 2009·Journal of Experimental & Clinical Cancer Research : CR·Aldo Venuti
Oct 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akio OhtaMichail Sitkovsky
Mar 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eileen M HighamJianzhu Chen
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Derese GetnetCharles G Drake
Oct 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qifeng ZhouYukai He
Sep 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cassie K ChouPhilip D Greenberg
Nov 13, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Salvatore FiorenzaIan H Frazer
Apr 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Haiyan XiaoYukai He
Dec 16, 2019·Cellular and Molecular Life Sciences : CMLS·Ziqiang WangWeiren Huang
Jul 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·S Peter BakJianzhu Chen
Apr 30, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eileen M HighamJianzhu Chen
Oct 20, 2020·Frontiers in Immunology·Simone NüssingIan A Parish
Apr 30, 2014·Cancer Immunology Research·S Peter BakJianzhu Chen
Jun 25, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shengjun LuJennifer D Wu

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