Rapid transport of noradrenaline in adrenergic axons of rat sciatic nerve distal to a crush.

Acta Physiologica Scandinavica
J HäggendalP A Larsson

Abstract

The transport of NA in the rat sciatic nerve distal to a crush was studied in 5 mm segments. The disappearance of a NA fraction in consecutive segments with time after crushing (0-12 h) was interpreted to indicate a proximo-distal migration of a NA fraction into further distal parts of the nerve. This transportable NA fraction was found to be about 45% of the NA in normal sciatic nerves and migrated at a rate of approximately 8 mm/h. The apparently non-mobile fraction (55%) was probably mainly located in vaso-constrictor nerve terminals of the blood vessels supplying the nerve. This non-mobile NA fraction does not contribute to the NA accumulations proximal to a crush. Thus, when calculating the rate of transport of any substance from accumulation experiments, corrections for a non-mobile fraction must always be considered.

References

Aug 1, 1975·Acta Physiologica Scandinavica·A DahlströmP A Larsson
Jul 1, 1971·The Journal of Pharmacy and Pharmacology·C J HäggendalA B Dahlström
Jan 1, 1969·Journal of Neurobiology·S Ochs, N Ranish
May 1, 1973·Journal of Neurochemistry·G F Wooten, J T Coyle
Aug 30, 1973·Brain Research·C J HäggendalN R Saunders
Nov 23, 1973·Brain Research·A Dahlström
Oct 1, 1969·The Journal of Pharmacy and Pharmacology·A Dahlström, J Häggendal
Apr 1, 1972·European Journal of Pharmacology·W G McLean, P Keen
Jan 1, 1974·Journal of Neural Transmission·A B DahlströmN R Saunders
Jul 1, 1966·Acta Physiologica Scandinavica·A Dahlström, J Häggendal
Oct 1, 1959·The Journal of Comparative Neurology·L LUBINSKA

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Citations

Jan 1, 1983·Journal of Neural Transmission·I Evers-Von Bültzingslöwen, J Häggendal
Aug 1, 1975·Acta Physiologica Scandinavica·A DahlströmP A Larsson
Apr 1, 1981·Acta Physiologica Scandinavica·A C Jönsson, S Nilsson
Sep 1, 1985·Acta Physiologica Scandinavica·G FriedE Theodorsson-Norheim
Dec 17, 2009·Progress in Neurobiology·Annica B Dahlstrom

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