Rapid ultra-trace analysis of sucralose in multiple-origin aqueous samples by online solid-phase extraction coupled to high-resolution mass spectrometry

Analytical and Bioanalytical Chemistry
Sudha Rani BatchuPiero R Gardinali

Abstract

Because of its widespread consumption and its persistence during wastewater treatment, the artificial sweetener sucralose has gained considerable interest as a proxy to detect wastewater intrusion into usable water resources. The molecular resilience of this compound dictates that coastal and oceanic waters are the final recipient of this compound with unknown effects on ecosystems. Furthermore, no suitable methodologies have been reported for routine, ultra-trace detection of sucralose in seawater as the sensitivity of traditional liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis is limited by a low yield of product ions upon collision-induced dissociation (CID). In this work, we report the development and field test of an alternative analysis tool for sucralose in environmental waters, with enough sensitivity for the proper quantitation and confirmation of this analyte in seawater. The methodology is based on automated online solid-phase extraction (SPE) and high-resolving-power orbitrap MS detection. Operating in full scan (no CID), detection of the unique isotopic pattern (100:96:31 for [M-H](-), [M-H+2](-), and [M-H+4](-), respectively) was used for ultra-trace quantitation and analyte identification. The ...Continue Reading

References

Mar 17, 2010·Analytical and Bioanalytical Chemistry·Martin KraussJuliane Hollender
Jan 18, 2011·Environmental Science & Technology·Lindsay SohJulie Zimmerman
Sep 2, 2011·Environmental Science & Technology·Douglas B MawhinneyShane A Snyder
Mar 1, 2012·Analytical and Bioanalytical Chemistry·F HernándezL Mattioli
Oct 4, 2012·The Science of the Total Environment·Knut Erik TollefsenDuane B Huggett
Apr 18, 2013·Analytical Chemistry·Roman A Zubarev, Alexander Makarov
Sep 7, 2013·Analytical Chemistry·Imma FerrerE Michael Thurman
Nov 13, 2013·Analytical and Bioanalytical Chemistry·Cesar E RamirezPiero R Gardinali
Apr 2, 2014·Environmental Science and Pollution Research International·Virender K SharmaHyunook Kim

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Citations

Aug 5, 2020·Bulletin of Environmental Contamination and Toxicology·Autumn HendersonPiero Gardinali

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