Rapid upregulation of heart antioxidant enzymes during arousal from estivation in the Giant African snail (Achatina fulica)

Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Kurtis D SalwayJeffrey A Stuart

Abstract

Estivation is an adaptive response to environments characterized by elevated temperatures and desiccative stress, as may occur during summer dry seasons. Similar to diapause and hibernation, it is characterized by low levels of activity, a drastically suppressed metabolic rate and enhanced stress resistance. We tested the hypothesis that Achatina fulica, a pulmonate land snail, enhances stress resistance during estivation and/or arousal by upregulating intracellular antioxidant defenses in the heart, kidney, hepatopancreas and foot tissues. No statistically significant changes in mitochondrial or cytosolic superoxide dismutase levels or activities, or glutathione peroxidase, glutathione reductase or catalase activities were associated with estivation in any tissue, however. In contrast, during arousal from estivation, activities of several antioxidant enzymes increased in heart, hepatopancreas and foot. In heart, a rapid increase in MnSOD protein levels was observed that peaked at 2h post arousal, but no such change was observed in CuZnSOD protein levels. Glutathione peroxidase activity was upregulated at 1h post arousal and remained elevated until 8h post arousal in heart tissue. Glutathione peroxidase was also upregulated at ...Continue Reading

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Citations

Feb 7, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Daniel C MoreiraMarcelo Hermes-Lima
Sep 27, 2015·Free Radical Biology & Medicine·Marcelo Hermes-LimaÉlida G Campos
Jul 5, 2016·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Muyan ChenTianming Wang
Jan 1, 2018·The African Archaeological Review·Jennifer M MillerPamela R Willoughby

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