Rapidity of plasma 1,25-dihydroxyvitamin D responses to hypo- and hypercalcemia in steers

Endocrinology
J W BlumJ A Fischer

Abstract

Experiments were designed to study the rapidity of changes in plasma 1,25-dihydroxyvitamin D [1,25-(OH)2D] levels in response to hypercalcemia and hypocalcemia induced by 10-h infusions of CaCl2 or EGTA in steers. In response to CaCl2 infusions, 1,25-(OH)2D was decreased within 4 h (P less than 0.05) and remained lower (P less than 0.05) than preinfusion concentrations for up to 14 h after termination of the infusions. PTH and inorganic phosphate (Pin) transiently decreased in response to the CaCl2 infusions, whereas total magnesium (Mg) continuously fell for up to 24 h after the start of the infusions. In response to infusions with EGTA, on the other hand, 1,25-(OH)2D continuously increased and was raised significantly (P less than 0.05) between 12 and 24 h after the start of the infusions. PTH increased within 2 h (P less than 0.05) and remained elevated (P less than 0.05) for up to 2 h after the end of the EGTA infusions, whereas Pin and Mg were not significantly changed. During and after 10-h control infusions of sodium chloride, the levels of 1,25-(OH)2D, PTH, Ca, Ca++, Pin, and Mg remained unaltered. In conclusion, plasma levels of 1,25-(OH)2D were lowered in response to hypercalcemia within 4 h and increased in response ...Continue Reading

Citations

Dec 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J R WeisingerD A Bushinsky
Jul 1, 1988·Journal of Neuroimmunology·R H KermanE S Sears
Mar 12, 1999·The Surgical Clinics of North America·A JainJ J Fung
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Mar 14, 2009·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Yo-ichi Nabeshima
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Feb 1, 1989·The American Journal of Physiology·S C KukrejaM J Favus
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