Abstract
Tumour necrosis factor (TNF) inhibitors are used against a variety of connective tissue diseases, including rheumatoid arthritis. Contrarily, although rare, TNF inhibitors are known to induce autoimmune diseases, such as systemic lupus erythematosus and psoriasis as a paradoxical reaction. We experienced a case of rapidly progressive glomerulonephritis after introduction of certolizumab pegol. The patient was a 30-year-old woman who was previously diagnosed with rheumatoid arthritis in X-8. She received treatment with methotrexate (8 mg/week) and infliximab (3 mg/kg/8 weeks), following which she showed low disease activity and remission. In September X-1, methotrexate and infliximab were discontinued and certolizumab pegol was introduced because she desired to bear children. In March X, the patient experienced renal dysfunction, and urinary protein analysis revealed positivity for myeloperoxidase anti-neutrophil cytoplasmic autoantibody. Renal biopsy showed crescentic glomerulonephritis, and the patient was diagnosed with rapidly progressive glomerulonephritis due to TNF inhibitor-induced microscopic polyangiitis. As she desired to bear children, rituximab was introduced in addition to corticosteroids, which led to remission of...Continue Reading
References
Jul 10, 2003·Autoimmunity Reviews·Elena Csernok
Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
Oct 16, 2004·Clinical Nephrology·T W R DoultonN Velasco
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·A Karolina PaluckaJacques Banchereau
Apr 21, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael B StokesVivette D D'Agati
Sep 2, 2006·Arthritis and Rheumatism·Stanley B CohenUNKNOWN REFLEX Trial Group
Feb 21, 2007·Archives of Dermatology·Gillian C de GannesJan P Dutz
Jul 17, 2007·Medicine·Manuel Ramos-CasalsMunther A Khamashta
Aug 23, 2007·Clinical Rheumatology·Dayavathi AshokIan Tomlinson
Feb 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Roslyn SimmsR Stuart Rodger
May 19, 2009·Nature Medicine·Kai KessenbrockDieter E Jenne
Apr 21, 2010·Rheumatology·Ketna ParekhLisa K Stamp
Jul 22, 2010·The New England Journal of Medicine·Rachel B JonesUNKNOWN European Vasculitis Study Group
Mar 11, 2011·Science Translational Medicine·Roberto LandeMichel Gilliet
Jun 16, 2012·Acta Medica (Hradec Králové)·Marian TosovskýJan Brozík
Feb 7, 2013·Dermatologic Therapy·Valentina BroshtilovaMary Gantcheva
Apr 10, 2013·The American Journal of Case Reports·Tatiana Reitblat, Olga Reitblat
Jan 5, 2014·Journal of the American Society of Nephrology : JASN·Daigo NakazawaAkihiro Ishizu
Apr 8, 2014·International Journal of Rheumatic Diseases·Vincenzo BruzzeseAngelo Zullo
May 28, 2015·International Journal of Rheumatic Diseases·Ahmed M Alkhunaizi, Mohamad F Dawamneh
Oct 4, 2015·Journal of Leukocyte Biology·Peter C Grayson, Mariana J Kaplan
Feb 19, 2016·Annals of the Rheumatic Diseases·Carina Götestam SkorpenMonika Østensen
Mar 25, 2017·Current Neurology and Neuroscience Reports·Elissavet Kemanetzoglou, Elisabeth Andreadou
Nov 14, 2019·Arthritis Research & Therapy·Michel De Bandt