Rapidly progressive glomerulonephritis due to coexistent anti-glomerular basement membrane disease and fibrillary glomerulonephritis

Clinical Kidney Journal
Wisit CheungpasitpornMariam P Alexander

Abstract

Anti-glomerular basement membrane (anti-GBM) disease is a major cause of rapidly progressive glomerulonephritis (RPGN). On the other hand, fibrillary glomerulonephritis (GN) typically presents as proteinuria, hematuria and renal insufficiency, but rarely as RPGN. Without electron microscopy, the diagnosis of fibrillary GN can be missed. We report a 68-year-old white woman who presented with RPGN with kidney biopsy demonstrating diffuse crescentic GN on light microscopy. By immunofluorescence, there was bright linear staining of the GBMs and smudgy mesangial staining for immunoglobulin G, C3, and kappa and lambda light chain. Electron microscopy revealed fibrillary deposits in the GBM and mesangium. A serum test for anti-GBM antibody was positive. To our knowledge, this is the first report of coexistence of fibrillary GN in a patient with anti-GBM disease. Electron microscopy is critical to identify the coexistence of other GN in patients presenting with crescentic GN.

References

Dec 1, 1992·Kidney International·S S IskandarJ C Jennette
Feb 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C E Alpers
Mar 1, 1987·Kidney International·C E AlpersC G Biava
Jun 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W G Couser
Sep 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A FogoR G Horn
May 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P H PronovostH G Rennke
Dec 10, 1998·American Journal of Nephrology·I IwamotoT Kurita
Jan 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A XenocostasM Levy
May 1, 2001·Pathology International·M NagataT Watanabe
Jun 5, 2003·Springer Seminars in Immunopathology·Dorin-Bogdan Borza, Billy G Hudson
Sep 13, 2003·Kidney International·Charles D Pusey
Oct 2, 2004·Kidney International·Jeremy B LevyCharles D Pusey
Mar 25, 2005·Journal of the American Society of Nephrology : JASN·Dominik WolfAlexander R Rosenkranz
Nov 25, 2005·International Urology and Nephrology·Sandeep MahajanS C Dash
Dec 1, 2005·Ultrastructural Pathology·Y CollanK Metsärinne
Jan 25, 2008·Journal of the American Society of Nephrology : JASN·Juan ZouRichard G Phelps
Jul 28, 2010·The New England Journal of Medicine·Vadim PedchenkoBilly G Hudson
Mar 29, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Samih H NasrFernando C Fervenza
Feb 9, 2012·Advances in Anatomic Pathology·Neeraja Kambham
Mar 9, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Purva SharmaDuvuru Geetha

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Methods Mentioned

BETA
electron microscopy
biopsy
enzyme-linked immunosorbent assay
electrophoresis
X-ray
light microscopy

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