PMID: 6397513Jun 1, 1983Paper

Rapidly reversible albumin and beta 2-microglobulin hyperexcretion in recent severe essential hypertension

Journal of Hypertension
C K Christensen

Abstract

Seven young patients with newly diagnosed severe hypertension were studied for one week. The mean age was 34.9 years (range 28-44). The mean initial values +/- s.d. for systolic and diastolic pressures were 223 +/- 27 and 141 +/- 8 mmHg, respectively. Secondary hypertension was excluded by conventional methods and serum creatinine was normal. A pronounced but quite variably elevated albumin excretion 440 +/- 448 micrograms/min (mean +/- s.d.) and a moderately increased beta 2-microglobulin excretion 3.06 +/- 3.29 micrograms/min was noted before treatment. The abnormal albumin excretion with ensuing fall in blood pressure was rapidly and almost completely reversible in all but one patient during conventional treatment and the increased beta 2-microglobulin excretion was totally reversible in all but one patient. Both albumin and beta 2-microglobulin excretion rate were positively correlated to arterial pressures in all patients. Thus glomerular and to some extent tubular protein handling were both affected in untreated patients, but rapidly reversible during initial antihypertensive treatment. The data indicate that the beta 2-microglobulin hyperexcretion is secondary to enhanced filtration of plasma protein saturating the tubul...Continue Reading

Citations

Jan 1, 1994·Journal of Clinical Laboratory Analysis·I J Alosachie, P M Lad
Jan 1, 1986·European Journal of Clinical Pharmacology·L R KrusellO Lederballe Pedersen
Aug 13, 2008·Current Opinion in Nephrology and Hypertension·Irena Duka, George Bakris
Jan 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·P MartinM H Stickland
Jan 1, 1989·Archives of Disease in Childhood·D M GibbT M Barratt
Dec 8, 2004·Blood Pressure·Paolo Verdecchia, Gian Paolo Reboldi
Apr 27, 1992·The American Journal of Medicine·N M Kaplan
Feb 1, 1987·Kidney International·C E Mogensen
Sep 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·A ChachatiP J Lefèbvre
Dec 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J NarvarteG Ramirez
Feb 19, 2002·Journal of Human Hypertension·R PedrinelliM Mariani
Oct 31, 1998·Journal of Hypertension·D Susic, E D Frohlich

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