Rare and common paraoxonase gene variants in amyotrophic lateral sclerosis patients

Neurobiology of Aging
Marka van BlitterswijkLeonard H van den Berg

Abstract

Polymorphisms in the paraoxonase family (PON) have been reported in patients with amyotrophic lateral sclerosis (ALS), but a recent meta-analysis did not show a clear association. Recently, PON mutations have also been identified in ALS patients. In this study, we assessed the frequency of PON variants in 1118 sporadic ALS patients, 93 familial ALS patients, and 1240 control subjects of Dutch descent. We identified PON mutations in 1.4% of sporadic ALS patients, 2.1% of familial ALS patients, and 2.5% of control subjects. There were no significant differences in mutational burden for rare variants or in allele frequencies of polymorphisms between patients and control subjects. Thus, this study does not support the premise that mutations or polymorphisms in PON contribute to ALS susceptibility.

References

Jun 29, 2010·Annals of Neurology·Nicola TicozziJohn E Landers

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Citations

Jul 28, 2013·International Journal of Molecular Sciences·Francesca TrojsiGioacchino Tedeschi
Aug 19, 2014·Neurobiology of Disease·David A HottmanLing Li
Mar 25, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Federico VerdeNicola Ticozzi
Dec 31, 2020·Antioxidants·Cadiele Oliana ReichertSergio P Bydlowski

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