Rare Cytogenetic Abnormalities and Alteration of microRNAs in Acute Myeloid Leukemia and Response to Therapy

Oncology Reviews
Mohammad ShahjahaniNajmaldin Saki

Abstract

Acute myeloid leukemia (AML) is the most common acute leukemia in adults, which is heterogeneous in terms of morphological, cytogenetic and clinical features. Cytogenetic abnormalities, including karyotype aberrations, gene mutations and gene expression abnormalities are the most important diagnostic tools in diagnosis, classification and prognosis in acute myeloid leukemias. Based on World Health Organization (WHO) classification, acute myeloid leukemias can be divided to four groups. Due to the heterogeneous nature of AML and since most therapeutic protocols in AML are based on genetic alterations, gathering further information in the field of rare disorders as well as common cytogenetic abnormalities would be helpful in determining the prognosis and treatment in this group of diseases. Recently, the role of microRNAs (miRNAs) in both normal hematopoiesis and myeloid leukemic cell differentiation in myeloid lineage has been specified. miRNAs can be used instead of genes for AML diagnosis and classification in the future, and can also play a decisive role in the evaluation of relapse as well as response to treatment in the patients. Therefore, their use in clinical trials can affect treatment protocols and play a role in thera...Continue Reading

Citations

Nov 16, 2018·Journal of Cellular Physiology·Ali Amin AsnafiTina Vosughi
May 14, 2019·Journal of Cellular Biochemistry·Hossein SharifiMohsen Taghizadeh
Nov 2, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·H Q MuY H Chen
Jan 24, 2020·Signal Transduction and Targeted Therapy·Hua JiangKang Zhang
Apr 17, 2020·Signal Transduction and Targeted Therapy·Hua JiangKang Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
chromosomal aberrations
PCR
GTPases
histone acetylation

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Related Papers

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Qing-xiang MengJun Wang
Romanian Journal of Physiology : Physiological Sciences
A Cucuianu
© 2022 Meta ULC. All rights reserved